Džubák Petr M.D., Ph.D.

Journals

IVASECHKO, I., A. LOZYNSKYI, J. SENKIV, P. ROSZCZENKO, Y. KOZAK, N. FINIUK, O. KLYUCHIVSKA, N. KASHCHAK, N. MANKO, Z. MASLYAK, D. LESYK, A. KARKHUT, S. POLOKVOVYCH, R. CZARNOMYSY, O. SZEWCZYK, A. KOZYTSKIY, O. KARPENKO, D. KHYLUK, A. GZELLA, K. BIELAWSKI, A. BIELAWSKA, P. DŽUBÁK, S. GURSKÁ, M. HAJDÚCH, R. STOIKA, R. LESYK
Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone). European Journal of Medicinal Chemistry. 2023, 252, 115304, ISSN: 0223-5234, PMID: 37001390,  PDF.
OŽDIAN, T., J. VODICKA, J. DOSTÁL, D. HOLUB, J. VÁCLAVKOVÁ, M. JESETA, B. HAMERNÍKOVÁ, P. KOUŘILOVÁ, O. MALCHAR, V. DVORAK, P. HEJTMANEK, K. SOBKOVA, P. VENTRUBA, R. PILKA, P. DŽUBÁK, M. HAJDÚCH
Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders. International Journal of Molecular Sciences. 2023, 24(2), 1038, ISSN: 1422-0067, PMID: 36674559,  PDF.
JURÁŠEK, M., J. ŘEHULKA, L. HRUBÁ, A. IVANOVA (NIKONENKO), S. GURSKÁ, O. MOKSHYNA, P. TROUSIL, K. HUML, P. POLISHCHUK, M. HAJDÚCH, P. DRAŠAR, P. DŽUBÁK
Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition. Bioorganic Chemistry. 2023, 131(2023), 106334, ISSN: 0045-2068, PMID: 36592487,  PDF.

Books & book chapters

DŽUBÁK, P., M. URBAN, M. HAJDÚCH
Vývoj nových léčiv, 1. vyd, Praha, Galén, 2015, 11, 469-472, ISBN: 978-80-7492-121-6,
CIBIČEK, N., J. VACEK, M. BERANEK, P. DŽUBÁK, Z. HEŘMANOVÁ, P. KOSINA, M. KUBALA, M. NOVÁK, B. PAPOUSKOVA, J. SROVNAL, J. VÁVROVÁ, J. VOSTALOVA, M. ZATLOUKALOVA, H. ŽIVNÁ
Hmotnostní spektrometrie, 1. vyd, Olomouc, Univerzita Palackého v Olomouci, 2014, 2.2, 34-40, ISBN: 978-80-244-3951-8,
CIBIČEK, N., J. VACEK, M. BERANEK, P. DŽUBÁK, Z. HEŘMANOVÁ, P. KOSINA, M. KUBALA, M. NOVÁK, B. PAPOUSKOVA, J. SROVNAL, J. VÁVROVÁ, J. VOSTALOVA, M. ZATLOUKALOVA, H. ŽIVNÁ
Elektrochemické metody, (bio)senzory a čipové platformy, 1. vyd, Olomouc, Univerzita Palackého v Olomouci, 2014, 2.3, 43-44, ISBN: 978-80-244-3951-8,

Intellectual property

BENZOISOTHIAZOLE-1, 1-DIOXIDE-3-HYDRAZONES AND THEIR USE IN ANTICANCER THERAPY (Kaplánek)
  1. Patent: CZ 306554; Granted: 25.1 2017; Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS; Inventors: Kaplánek Robert, Bříza Tomáš, Havlík Martin, Rak Jakub, Kejík Zdeněk, Džubák Petr, Hajdúch Marián, Konečný Petr, Štěpánková Jana, Králová Jarmila, Král Vladimír

​Status: Terminated

SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE (Hocek)
  1. Published application PCT/CZ2017/050031 under WO 2018/024265 (8.2.2018)
  2. Patent: CZ 307334. Granted: 2.5.2018. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacky University, Olomouc. Inventors: Hocek Michal, Tokarenko Anna, Smoleń Sabina, Džubák Petr, Hajdúch Marián
  3. Patent: EP 3494122. Granted: 18.9.2019. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacky University, Olomouc. Inventors: Hocek Michal, Tokarenko Anna, Smoleń Sabina, Džubák Petr, Hajdúch Marián
  4. Patent: JP 6685475. Granted: 2.4.2020. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacky University, Olomouc. Inventors: Hocek Michal, Tokarenko Anna, Smoleń Sabina, Džubák Petr, Hajdúch Marián
  5. Patent: US 10,730,905. Granted: 4.8.2020. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacky University, Olomouc. Inventors: Hocek Michal, Tokarenko Anna, Smoleń Sabina, Džubák Petr, Hajdúch Marián
  6. Patent: CA 3,031,049. Granted: 7.7.2020. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacky University, Olomouc. Inventors: Hocek Michal, Tokarenko Anna, Smoleń Sabina, Džubák Petr, Hajdúch Marián

Status: Available

CULTURE DISH (Džubák)
  1. Utility Model: CZ 28806, Granted: 10.11.2015, Ownership: Palacky University Olomouc, Inventors: Džubák Petr, Hajdúch Marián
  2. Design: CZ 36622, Granted: 28.12.2015, Ownership: Palacky University Olomouc, Inventors: Džubák Petr, Hajdúch Marián
  3. Registered Community Design: RCD 003039577-0001, Granted: 23.3.2016, Ownership: Palacky University Olomouc, Inventors: Džubák Petr, Hajdúch Marián
  4. Registered Community Design: RCD 003039577-0002, Granted: 23.3.2016, Ownership: Palacky University Olomouc, Inventors: Džubák Petr, Hajdúch Marián
  5. EP 3147347, Granted: 6.5.2020, Ownership: Palacky University Olomouc, Inventors: Džubák Petr, Hajdúch Marián

Status: Available 

Doctoral mentorship

Konečný Petr M.Sc.

Screening of chemical compounds´ biological activities in vitro

Status: Graduated from 2010 to 2016.
Rylová Gabriela M.Sc.

Identification of molecular targets of anticancer drugs by proteomic methods

Status: Graduated from 2009 to 2009.
Uniyal Vaishali

Kinase inhibitors in treatment of neurodegenerative disease

Status: Ongoing from 2018 to 2018.

Master mentorship

Václavková Jana M.Sc.

Proteomic profile of anticancer effect of clinically used plant alkaloids

Status: Graduated from 2011 to 2013.

Open positions

Project: Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Antitumor drugs targeting nucleic acid metabolism
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Identification of molecular targets and mechanisms of resistance in antitumor drugs using cell biology and proteomics methods
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Genetic and epigenetic biomarkers of cancer diseases
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 places in full-time study
Project: Identification of proteomic biomarkers in exhaled breath condensate in patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Ph.D. topic is focused on the identification of biomarkers of lung diseases by means of a non-invasive collection of exhaled breath condensate. The project will monitor the presence of proteins in exhaled air in various diseases such as asthma, cystic fibrosis, lung tumors, or some infectious diseases, as well as quantitative changes of these proteins compared to a healthy population. Changes in these potential biomarkers with respect to therapeutic response and disease progression will be evaluated and validated.
Project: Identification of molecular targets of anticancer therapy applying cell biology and proteomics tools
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Selected, highly active derivatives of triterpenes, chelators and nucleosides will be studied with a view to identify the mechanisms of their antitumor effects. Advanced methods of cell biology, proteomics and genomics such as affinity purification of protein targets, CETSA and others will be used for their study. The identified targets will be validated in relation to their clinical relevance in anticancer therapy.
Project: Drug resistance mechanisms in cancer
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Mechanisms of tumor cell resistance to newly developed and existing nucleoside analog cytostatics will be studied. These drugs are used in most anti-cancer therapy protocols and the emergence of drug resistance is a major problem in the treatment of cancer patients. Resistant cell lines prepared in the past will be studied to identify the key mechanisms of resistance, which will be carried out by their detailed characterization using cell biology, but also proteomics and molecular genetics. The significance of the identified changes will be further verified on clinical material and will be applied in the development of new anticancer drugs from this class.
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Genetic and epigenetic biomarkers in health and disease
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
Available: 5
Intended for: Doctoral training
Project: Identification of molecular targets and resistance mechanisms of anticancer drugs by cell biology and proteomics methods
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in proximal fluids and tissues
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Innovative approaches to protein interaction modifiers
Supervisors: Džubák Petr M.D., Ph.D., Václavková Jana M.Sc.
Available: 1
Intended for: Doctoral training
Project: Utilization of the space of unprecedented covalent inhibitors
Supervisors: Džubák Petr M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Project: Anticancer drugs targeting nucleic acid metabolism
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training