Steigerová Jana Ph.D.
About me
My main research focus is molecular biology of hormone sensitive tumours; study of roles of nuclear receptors in cancer development and progression; cell cycle and apoptosis regulation; natural alkaloids, brassinosteroids and steroid derivatives that target nuclear receptors; novel anticancer drugs. Author of 16 papers in impacted journals (WOS), 2 patents, citations 490; h-index = 8. Tutor of bachelory, diploma and doctoral thesis.
Journals
Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram. The Prostate. 2018, 79(4), 352-362, ISSN: 0270-4137, PMID: 30499118,
The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitro. The Journal of Steroid Biochemistry and Molecular Biology. 2018, 178, 263-271, ISSN: 0960-0760, PMID: 29307714,
Doctoral mentorship
Hušková Zlata B.Sc.
Molecular mechanisms of action of plant steroids on tumor cells
Status: Graduated from 2015 to 2020.
Master mentorship
Hušková Zlata B.Sc.
Molecular mechanisms of plant steroids and study of their receptor interactions in cancer cells
Status: Graduated from 2013 to 2015.