Koudeláková Vladimíra Ph.D.
Academic title: M.Sc., Ph.D.
E-mail: vladimira.koudelakova@upol.cz
Phone: +420 585632089
Groups: IMTM, LEM, STAFF
About me
Scientist involved in molecular and translational medicine (disease area oncology and infectious diseases), Vice-Director of Healthcare with specialization in clinical genetics and leader of Virology and molecular carcinogenesis research group.
Specialties: Molecular and translational medicine, Oncology, Virology, Molecular carcinogenesis and HPV-driven cancers.
Responsibility for clinical diagnostics and healthcare staff management, next-genome sequencing, virus-driven infections, and carcinogenesis research. Teaching and examination of students, tutor for bachelor, master, and PhD. students.
Journals
BCL2 is an independent predictor of outcome in basal-like triple-negative breast cancers treated with adjuvant anthracycline-based chemotherapy. Tumor Biology. 2015, 36(6), 4243-52, ISSN: 1010-4283, PMID: 25616695,
Isocitrate dehydrogenase 1 and 2 mutations in gliomas. Journal of Neuroscience Research. 2014, 92(12), 1611-1620, ISSN: 0360-4012, PMID: 25078896,
Open positions
1 Pathophysiology and new drug targets
| Project: | Pathological conditions associated with human papillomavirus infection |
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| Supervisors: | Koudeláková Vladimíra Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | High-risk human papillomavirus infection (HPV infection) is associated with several cancers such as cervical, vaginal, vulvar, head and neck, anal, and penile carcinomas. Nearly all cervical cancers are caused by HPV infection. Despite available vaccination and cervical cancer screening program, cervical cancer is one of the most common types of cancer affecting women worldwide. Main problems of cervical cancer screening are low participation rate and low sensitivity of cytology which is still used in the majority of cervical cancer screening programs. Solution could be the transition to primary HPV screening and the sending of self-sampling devices to cervical cancer screening non-attenders. The best strategy for enrolling Czech women in the screening program will be analysed during this project. Obtained samples will be tested for the presence of HPV DNA and the presence of other molecular biomarkers important in viral clearance and cervical cancer progression/regression. Discoveries will lead to identification of biomarkers for early diagnosis, disease progression or triage strategies. The aim of the project is to clarify the best strategy for enrolling women who do not attend cervical cancer screening program. The second aim is to study genetic and proteomic profile of HPV positive/negative women with normal/abnormal cervical cytology as well as genetic variants of HPV and its importance for regression/progression of the disease. Skills to be taught include biochemistry, molecular biology, bioinformatics and cell culture. This is an ideal project for a student who wishes to pursue higher studies in cancer research. The project will use various techniques including PCR, in situ hybridization, next generation sequencing, mass spectrometry. |
3 Molecular and Translational Medicine
| Project: | Genetic and epigenetic biomarkers in health and disease |
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| Supervisors: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 5 |
| Intended for: | Doctoral training |
| Project: | New prognostic and predictive factors in solid tumors |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |
| Project: | Liquid biopsies in experimental and clinical oncology |
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| Supervisors: | Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |