Džubák Petr M.D., Ph.D.
E-mail:
petr.dzubak@upol.cz
Telefon:
+420 585632150, +420 604851158
Skupiny:
ÚMTM, LEM, PERSONÁL, VEDOUCÍ
O mně
Scientist and pediatrician involved in molecular and translational medicine (disease area oncology and infectious diseases), leader of research program Chemical Biology and Experimental Therapeutics at IMTM. Actively participated in the research of more than 20 national and international projects; member of advisory board of Cancer Research Foundation „Rakovina ve veřejná“, co-founder of spin-off company focused on manufacturing of molecular diagnostics. Published more than >140 papers and books/chapters, >3552 SCI citations, H-index 27, Prix de Pharmacie 2007 Ambassade de France – Sanofi-aventis, Premier Prix.
Specialties: Molecular and translational medicine, Oncology, Drug research and development, MOA, Drug resistance
Journals
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes.
European Journal of Medicinal Chemistry.
2022,
244,
114850,
ISSN: 0223-5234,
PMID: 36283179,
Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling.
Journal of the American Chemical Society.
2022,
144(42),
19437-19446,
ISSN: 0002-7863,
PMID: 36245092,
Intellectual property
BENZOTHIAZOLE-SUBSTITUTED CYCLOBUT-3-ENE-1, 2-DIONE-3-HYDRAZONES AND THEIR USE IN THE TREATMENT OF VARIOUS TYPES OF LEUKEMIA AND TUMOUR DISEASES (Kaplánek)
- Patent: CZ 305538; Granted: 14.10.2015; Ownership: Institute of Chemical Technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS; Inventors: Kaplánek Robert, Bříza Tomáš, Havlík Martin, Rak Jakub, Kejík Zdeněk, Krejčí Petr, Džubák Petr, Hajdúch Marián, Štěpánková Jana, Konečný Petr, Králová Jarmila, Král Vladimír
Status: Terminated
CHOLYL HYDRAZONES AND THEIR USE IN THE TREATMENT OF TUMOR AND LEUKEMIA DISEASES (Rak)
- Patent: CZ 305607; Granted: 25.11.2015; Ownership: Institute of Chemical Technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS; Inventors: Rak Jakub, Kaplánek Robert, Štulcová Tereza, Drašar Pavel, Havlík Martin, Bříza Tomáš, Džubák Petr, Hajdúch Marián, Konečný Petr, Štěpánková Jana, Králová Jarmila, Král Vladimír
Status: Terminated
METHOD OF IDENTIFICATION OF ENTITIES FROM MASS SPECTRA (Hruška)
- Published Application EP 18184710.4 under EP 3598135 (22.1.2020)
- Published Application PCT/EP2019/069552 under WO 2020/016428 (23.1.2020)
- Published Application EP 19746050.4 under EP3824292 (26.5.2021)
- Patent: JP 7218019. Granted: 27.1.2023. Ownership: Palacký University Olomouc. Inventors: Hruška Miroslav, Hajdúch Marián
Status: Patents pending, Available
Doctoral mentorship
Oždian Tomáš Ph.D.
Cancer proteomics in clinical and experimental oncology
Stav:
Absolvoval od 2009 do 2016.
Balatková Pavlína
Experimental development of drugs and nanoparticles targeting prototoxic stress
Stav:
Probíhající od 2023.
Kroupová Denisa
Multi Omics analyzes of proximal fluids for the identification of novel biomarkers and molecular targets
Stav:
Probíhající od 2023.
Open positions
| Projekt: | Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Antitumor drugs targeting nucleic acid metabolism |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Identification of molecular targets and mechanisms of resistance in antitumor drugs using cell biology and proteomics methods |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Genetic and epigenetic biomarkers of cancer diseases |
|---|---|
| Vedoucí: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 3 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 3 places in full-time study |
| Projekt: | Identification of proteomic biomarkers in exhaled breath condensate in patients with systemic or pulmonary disease |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | Ph.D. topic is focused on the identification of biomarkers of lung diseases by means of a non-invasive collection of exhaled breath condensate. The project will monitor the presence of proteins in exhaled air in various diseases such as asthma, cystic fibrosis, lung tumors, or some infectious diseases, as well as quantitative changes of these proteins compared to a healthy population. Changes in these potential biomarkers with respect to therapeutic response and disease progression will be evaluated and validated. |
| Projekt: | Identification of molecular targets of anticancer therapy applying cell biology and proteomics tools |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | Selected, highly active derivatives of triterpenes, chelators and nucleosides will be studied with a view to identify the mechanisms of their antitumor effects. Advanced methods of cell biology, proteomics and genomics such as affinity purification of protein targets, CETSA and others will be used for their study. The identified targets will be validated in relation to their clinical relevance in anticancer therapy. |
| Projekt: | Drug resistance mechanisms in cancer |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | Mechanisms of tumor cell resistance to newly developed and existing nucleoside analog cytostatics will be studied. These drugs are used in most anti-cancer therapy protocols and the emergence of drug resistance is a major problem in the treatment of cancer patients. Resistant cell lines prepared in the past will be studied to identify the key mechanisms of resistance, which will be carried out by their detailed characterization using cell biology, but also proteomics and molecular genetics. The significance of the identified changes will be further verified on clinical material and will be applied in the development of new anticancer drugs from this class. |
| Projekt: | Research and development of agents for cancer, neurodegenerative and infectious diseases |
|---|---|
| Vedoucí: | De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D. |
| K dispozici: | 5 |
| Určeno pro: | Doktorské studium |
| Projekt: | Genetic and epigenetic biomarkers in health and disease |
|---|---|
| Vedoucí: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D. |
| K dispozici: | 5 |
| Určeno pro: | Doktorské studium |
| Projekt: | Identification of molecular targets and resistance mechanisms of anticancer drugs by cell biology and proteomics methods |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Projekt: | Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Projekt: | Identification of proteomic biomarkers in proximal fluids and tissues |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Projekt: | Innovative approaches to protein interaction modifiers |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Václavková Jana M.Sc. |
| K dispozici: | 1 |
| Určeno pro: | Doktorské studium |
| Projekt: | Utilization of the space of unprecedented covalent inhibitors |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D. |
| K dispozici: | 1 |
| Určeno pro: | Doktorské studium |
| Projekt: | Anticancer drugs targeting nucleic acid metabolism |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |