The European Advanced Translational Research Infrastructure in Medicine (EATRIS) provides integrated access to the combined expertise and high-end technologies for developing new products in translational medicine. During its first five years, it provided its services to a wide range of users such as academia, SMEs, large pharma and biotech research institutes. The EU-funded EATRIS-Plus project intends to support the long term sustainability (LTS) of the EATRIS by offering advanced scientific instruments to the academic community, improving its financial model and strengthening its leadership in the field of personalised medicine (PM).