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Voller Jiří Ph.D.

Journals

BÉRESOVÁ, L., E. VESELÁ, I. CHAMRAD, J. VOLLER, M. YAMADA, T. FÜRST, R. LENOBEL, K. CHROMÁ, J. GURSKÝ, K. KŘÍŽOVÁ, M. MISTRÍK, J. BÁRTEK
Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics. Journal of Proteome Research. 2016, 15(12), 4505-4517, ISSN: 1535-3893, PMID: 27794614,
JORDA, R., L. HAVLICEK, I. MCNAE, M. WALKINSHAW, J. VOLLER, A. STURC, J. NAVRATILOVA, M. KUZMA, M. MISTRÍK, J. BÁRTEK, M. STRNAD, V. KRYŠTOF
Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity. Journal of Medicinal Chemistry. 2011, 54(8), 2980-2993, ISSN: 0022-2623, PMID: 21417417,

Open positions

Projekt: Search and characterization of substances for the therapy of congenital or acquired diseases caused by aberrant splicing of pre-mRNA
Vedoucí: Voller Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 place in full-time study
Projekt: Physiology and pathophysiology of aging
Vedoucí: Hajdúch Marián M.D., Ph.D., Voller Jiří Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 places in full-time study
Projekt: Bio- and cheminformatics in biology of aging
Vedoucí: Voller Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: Although hundreds of biological databases are available, a richly annotated database of anti-aging compounds with diverse mechanisms of action has been missing. The aim of the project is to create a database of compounds with anti-aging activity that would offer a rich annotation of both compound and involved biological mechanisms. The data will be collected from a wide range of public databases, by text-mining of scientific literature and patents as well as from results of in-house high-throughput screening. The data will be used for formulation of new hypotheses of mechanisms of aging as well as for identification of novel anti-aging compounds.
Projekt: Screening and characterization of compounds for therapy of diseases caused by aberrant pre-mRNA splicing
Vedoucí: Voller Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: Recently, we identified several novel modulators of alternative splicing with the ability to increase expression of wild-type transcripts of several genes relevant for neurodegeneration or cancer. However, mechanisms of action of those promising compounds remains unclear. The aim of the project is to (i) identify molecular targets and relevant pathways, (ii) design assays for high-througput screening of a library of chemical compounds, and (iii) to identify novel structural types of active compounds.
Projekt: Screening and characterization of compounds for therapy of mitochondrial and metabolic disorders
Vedoucí: Voller Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: Pharmacotherapy of hereditary mitochondrial diseases including neurodegenerations and cardiopathies is only symptomatical at present. The aim of this study is to identify the novel candidate drugs by high-throughput screening using patient-derived cell lines. The assays will evaluate survival under metabolic and oxidative stress as well as morphology and function of mitochondria. Mechanism of action of promising compounds will be studied by OMICS methods.
Projekt: Identification of pro-longevity pathways and mechanisms of model organisms
Vedoucí: Voller Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: The aim of the project is to identify the novel compounds which can increase life-span of C. elegans, increase their resistance against stress and neurodegeneration, using high-throughput and high-content screening platforms. Active compounds will be further studied in human cell cultures. Mechanisms of action of interesting hits will be studied by OMICS
Projekt: Physiology and pathophysiology of ageing
Vedoucí: Hajdúch Marián M.D., Ph.D., Voller Jiří Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Search and characterization of compounds for the therapy of congenital or acquired diseases caused by aberrant pre-mRNA editing
Vedoucí: Voller Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Projekt: Search and study of the mechanism of action of new circadian rhythm modulators for the therapy of civilization diseases
Vedoucí: Voller Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Projekt: Search and study of the mechanism of action of substances affecting the viability and motility of human spermatozoa
Vedoucí: Voller Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium