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Mistrík Martin Ph.D.

Journals

Identification of novel dithiocarbamate-copper complexes targeting p97/NPL4 pathway in cancer cells. European Journal of Medicinal Chemistry. 2023, 261, 115790, ISSN: 0223-5234 , PMID: 37690264,
KANELLIS, D., A. ZISI, Z. ŠKROTT, B. LEMMENS, J. ESPINOZA, M. KOSAR, A. BJÖRKMAN, X. LI, S. ARAMPATZIS, J. BARTKOVA, M. ANDUJAR-SANCHEZ, O. FERNANDEZ-CAPETILLO, M. MISTRÍK, M. LINDSTROM, J. BÁRTEK
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET. Cell Death and Differentiation. 2023, ISSN: 1350-9047, PMID: 37142656,
BUCHTOVÁ, T., L. BÉRESOVÁ, K. CHROMÁ, T. PLUHACEK, T. BERES, D. KACZOROVA, P. TARKOWSKI, J. BÁRTEK, M. MISTRÍK
Cannabis-derived products antagonize platinum drugs by altered cellular transport. Biomedicine & Pharmacotherapy. 2023, 163, 114801, ISSN: 0753-3322, PMID: 37137184,

Books & book chapters

BUCHTOVÁ, T., M. MISTRÍK
Quantitative immunofluorescence microscopy , 1.vyd., Olomouc, Palacky University, 2021, 14, 89-100, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

MCOPPB FOR USE AS MEDICAMENT (Mistrík)
  1. Published Application EP 18166780.9 under EP 3552605 (16.10.2019)
  2. Published Application PCT/CZ2019/059320 under WO 2019/197564 (17.10.2019)

Status: Patent pending, Available

BIOAVAILABLE DITHIOCARBAMATE-METAL COMPLEX NANOPARTICLES, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM I" (Škrott)
  1. Patent: EP 3459526. Granted: 24.2.2021. Ownership: Palacky University, Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  2. Published Application PCT/EP2018/076098 under WO 2019/063601 (4.4.2019)
  3. Patent: AU 2018340510. Granted: 5.8.2021. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch MariánBártek JiříDžubák PetrZbořil Radek.
  4. Patent: CA 3,076,855. Granted: 26.4.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  5. Patent: KR 10-2456683. Granted: 14.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  6. Patent: JP 2020-537873. Granted: 29.9.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  7. Patent: MX 396,552. Granted: 17.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.

Status: Available

METHOD OF OBTAINING FOLLICULAR CELLS AND A DEVICE FOR CARRYING OUT THIS METHOD (Mistrík)
  1. Patent: CZ 304255; Granted: 18.12.2013; Ownership: Palacky University Olomouc; Inventors: Mistrík Martin, Bártek Jiří
  2. Published Application PCT/CZ2013/000152 under WO 2014/086324 (12.6.2014)
  3. Patent: US 9,943,331; Granted: 17.4.2018; Ownership: Palacky University Olomouc; Inventors: Mistrík MartinBártek Jiří
  4. Patent: EP 2928382; Granted: 26.12.2018; Ownership: Palacky University Olomouc; Inventors: Mistrík MartinBártek Jiří
  5. EU Registered Trademark: EUTM 018714735; Registered: 8.11.2022; Ownership: Palacky University Olomouc

Status: Available

Doctoral mentorship

Škrott Zdeněk Ph.D.

The role of the ubiquitin-proteasome system in tumorigenesis and cancer treatment

Stav: Absolvoval od 2014 do 2019.
Buchtová Tereza M.Sc.

Proteotoxic stress

Stav: Absolvoval od 2018 do 2023.
Veselá Eva M.Sc.

Application of quantitative microscopy analysis of DNA damage for study of cell response to γ-irradiation and radiomimetic compounds in different genetic backrounds.

Stav: Absolvoval od 2011 do 2017.

Master mentorship

Veselá Eva M.Sc.

Quantitative analysis of DNA damage markers and optimization of the methods for routine screening of potentially genotoxic compounds and factors

Stav: Absolvoval od 2009 do 2011.
Votroubek Ondřej

Effect of CuET and DNA damage inductors on DNA replication in cancer cells

Stav: Absolvoval od 2021 do 2023.

Bachelor mentorship

Veselá Eva M.Sc.

Identification and quantification of DNA damage in human cells

Stav: Absolvoval od 2008 do 2009.

Open positions

Projekt: DNA damage signaling in the cellular response to stress
Vedoucí: Mistrík Martin Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 place in full-time study
Projekt: Signaling DNA damage in cellular response to stress
Vedoucí: Mistrík Martin Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: Our DNA is constantly under threat from DNA damaging agents. If unrepaired DNA damage can lead to errors during genome duplication, including the mutations that can lead to cancer, contribute to aging and other human diseases. Cells have evolved elaborate repair mechanisms to fix this damage and ensure that the genetic information is faithfully reproduced, and we would like to understand these repair mechanisms at the molecular level. We ultimately aim for a complete molecular and cellular understanding of critical DNA repair pathways that act on DNA damage. The Ph.D. student will practice several molecular and cellular techniques, including cell culture, RNA interference, immunofluorescence microscopy, live-cell imaging and immunoprecipitation of proteins. He/she will also learn novel and powerful techniques, such as super-resolution microscopy and purification of proteins on newly synthesized DNA.
Projekt: Study of DNA double-strand break repair in tumor model
Vedoucí: Mistrík Martin Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: The so-called double-strand breaks (DSB) are the most lethal DNA lesions, which can be potent sources of mutations and thus become the beginning of irreversible genetic changes leading to degenerative illnesses, including cancer. At the same induction of DSBs introduced in the proper setup can become an unsolvable problem for the cells, particularly in specific genetic backgrounds typical for cancer, which fact is the rationale for a plethora of cancer treatment strategies. Thus the way cells deal with DSBs is under the great interest of current medicinal and biological research. The Ph.D. student will practice several methods of induction of DSBs via various sources such as gamma rays, alpha particles, UV light and various chemical inducers. Next will be studied the molecular mechanisms the cell deal with this type of DNA damage. Emphasis will be put on differences between normal and cancer cells and their potential exploration for cancer therapy. Student will also learn mutiple laboratory techniques including cell culture, RNA/DNA transfections, advanced microscopic techniques, live-cell imaging, and various biochemical analysis of proteins.
Projekt: Cellular stress in health and disease
Vedoucí: Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Projekt: DNA damage signaling in the cellular response to stress
Vedoucí: Mistrík Martin Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium