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Drábek Jiří Ph.D.

Journals

ŘEHULKOVÁ, A., J. CHUDÁČEK, A. PROKOPOVÁ, M. VIDLAŘOVÁ, J. STRÁNSKÁ, J. DRÁBEK, J. POTOČKOVÁ, R. TROJANEC, J. VRBKOVÁ, J. ŠKARDA, T. BOHANES, M. SZKORUPA, B. TOLMACI, J. KLEIN, J. SROVNAL, M. HAJDÚCH
Clinical and prognostic significance of detecting CEA, EGFR, LunX, c-met and EpCAM mRNA-positive cells in the peripheral blood, tumor-draining blood and bone marrow of non-small cell lung cancer patients. Translational Lung Cancer Research. 2023, 12(5), 1034-1050, ISSN: 2226-4477 , PMID: 37323172,
SLAVKOVSKÝ, R., J. STRÁNSKÁ, V. VĚNSKOVÁ, S. JANČÍK, L. KOTKOVÁ, P. VOJTA, P. FLODR, M. BARTOUŠKOVÁ, H. ŠTUDENTOVÁ, M. HAJDÚCH, J. DRÁBEK
Development and extensive analytical validation of deep amplicon sequencing for detecting KRAS and NRAS mutations in metastatic colorectal cancer samples. Neoplasma. 2021, 69(1), 203-2015, ISSN: 0028-2685, PMID: 34881628,
ZHAO, Y., L. FANG, T. SHEN, S. CHOUDHARI, K. TALSANIA, X. CHEN, J. SHETTY, Y. KRIGA, B. TRAN, B. ZHU, Z. CHEN, W. CHEN, C. WANG, E. JAEGER, D. MEERZAMAN, C. LU, K. IDLER, L. REN, Y. ZHENG, L. SHI, V. PETITJEAN, M. SULTAN, T. HUNG, E. PETERS, J. DRÁBEK, P. VOJTA, R. MAESTRO, D. GASPAROTTO, S. KOKS, E. REIMANN, A. SCHERER, J. NORDLUND, U. LIJEDAHL, J. FOOX, C. MASON, C. XIAO, H. HONG, W. XIAO
Whole genome and exome sequencing reference datasets from a multi-center and cross-platform benchmark study. Scientific Data. 2021, 8(1), 296, ISSN: 2052-4463, PMID: 34753956,

Books & book chapters

Genetic risk calculation of cystic fibrosis in prenatal testing, 1.vyd., Olomouc, Palacky University, 2021, 45, 357-366, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,
DRÁBEK, J., J. BERKOVCOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. KHOYLOU, V. KOUDELÁKOVÁ, J. SROVNAL, M. STAŇKOVÁ, R. TROJANEC
Detekce nádorových biomarkerů v molekulárně biologické laboratoři, 1. vyd, Olomouc, Univerzita Palackého v Olomouci, 2012, 144 s, Dedication: MOLONKOL CZ.1.07/2.3.00/09.0089, ISBN: 978-80-244-3002-7,

Intellectual property

Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer (Šurinová)
  1. Published Application PCT/EP2013/057111 under WO 2013/152989 (17.10.2013)

Status: Terminated

Postdoctoral mentorship

Stránská Jana Ph.D.

Biomarkers for prognostic and predictive purposes

Doctoral mentorship

Jančík Sylwia Ph.D.

New strategies for genotyping of KRAs and BRAF onkomarkesrs in heterogeneous clinical tumors samples

Stav: Absolvoval od 2009 do 2015.
Gyurka Kamil Levente

Cell line authentication using PCR High Resolution Melting Analysis

Stav: Probíhající od 2016 do 2016.
Urbanovská Irena

Genetic and epigenetic characterization of patients with glioblastoma

Stav: Probíhající od 2009 do 2009.

Master mentorship

Remešová Eliška

Bisulfite reaction alternatives for cytosine methylation detection

Stav: Probíhající od 2022.
Gabčová Gabriela B.Sc.

Detection of predictive genetic oncomarkers of EGFR signalling pathway using sequencing technologies

Stav: Absolvoval od 2010 do 2015.
Michalcová Kristýna

Epigenetic resolution monozygotic twins

Stav: Absolvoval od 2015 do 2017.

Bachelor mentorship

Fusek Karel

Snapback PCR

Stav: Absolvoval od 2015 do 2017.
Kadlčíková Dominika

Melting curve at microsatellite amplicons

Stav: Absolvoval od 2015 do 2017.
Gabčová Gabriela B.Sc.

Experimental design for CE mark of V600E BRAF genotyping kit

Stav: Absolvoval od 2011 do 2013.

Open positions

Projekt: Genetic and epigenetic biomarkers of cancer diseases
Vedoucí: Drábek Jiří Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 place in full-time study
Projekt: Genetic and epigenetic biomarkers in cancer
Vedoucí: Drábek Jiří Ph.D., Slavkovský Rastislav Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Souhrn: Clonal hematopoiesis of indeterminate potential (CHIP) has recently been described as a common phenomenon associated with aging. It is characterized by the accumulation of somatic mutations in cells of the hematopoietic system. Although CHIP is manifested by the expansion of certain cell clones, this condition is not accompanied by any morphological features of hematological neoplasia. However, it has been shown that the incidence of clonal hematopoiesis correlates with increased overall mortality and the risk of developing malignant transformation of hematopoietic cells as well as cardiovascular disease, such as ischemic stroke. To what extent and by what mechanisms clonal hematopoiesis contributes to disease development remains a question of current research. The main aim of the project will be to pinpoint the principal cells carrying CHIP somatic mutations, and to study their role in development and maintenance of atherosclerotic plaques, especially of those involved in development of stroke. The comparison of the phenotype of CHIP positive and negative cells will be of special interest. The use of cellular models not only include different types of leucocytes but circulatory progenitor endothelial cells as well. The study will involve elderly subjects with the positive presence of CHIP (>65 years). Subject will be characterized based on the presence or absence of ischemic stroke and the presence or absence of carotid stenosis by our clinical collaborators. The presence of somatic variants in 38 selected genes associated with CHIP will be tested in subjects of interest within our research group. The project will use various techiques including FACS, MACS, cell cultures, DNA isolation from small amount of cells, a highly sensitive sequencing method for DNA genotyping allowing detection of variant with less than 1% allelic frequency, DNA/RNA sequencing library preparation, deep massively parallel sequencing of panel of genes using unique molecular barcodes/indices, RNAseq, bioinformatics and data analysis with possibilities of calculations using high performance computing cluster, data management and statistical evaluation.
Projekt: Genetic and epigenetic biomarkers in health and disease
Vedoucí: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium
Projekt: Genetic biomarkers
Vedoucí: Drábek Jiří Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Projekt: Epigenetic biomarkers
Vedoucí: Drábek Jiří Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium