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Srovnal Josef M.D., Ph.D.

Journals

SPURNA, Z., P. CAPKOVA, L. PUNOVA, J. DUCHOSLAVOVÁ, D. ALEKSIJEVIC, J. VENHACOVA, J. SROVNAL, J. STELLMACHOVA, V. CURTISOVA, V. BITNEROVA, K. KOLARIKOVA, M. JANÍKOVÁ, R. KRATOCHVILOVA, P. VRTEL, R. VODICKA, R. VRTEL, J. ZAPLETALOVÁ
Clinical-genetic analysis of selected genes involved in the development of the human skeleton in 128 Czech patients with suspected congenital skeletal abnormalities. Gene. 2023, ISSN: 0378-1119, PMID: 37806643.
VECERA, L., P. PRASIL, J. SROVNAL, E. BERTA, M. VIDLAŘOVÁ, T. GABRHELIK, P. KOUŘILOVÁ, M. LOVEČEK, P. SKALICKÝ, J. ŠKARDA, Z. KALA, P. MICHALEK, M. HAJDÚCH
Morphine Analgesia, Cannabinoid Receptor 2, and Opioid Growth Factor Receptor Cancer Tissue Expression Improve Survival after Pancreatic Cancer Surgery. Cancers. 2023, 15(16), 4038, ISSN: 2072-6694, PMID: 37627066,  PDF.
ŘEHULKOVÁ, A., J. CHUDÁČEK, A. PROKOPOVÁ, M. VIDLAŘOVÁ, J. STRÁNSKÁ, J. DRÁBEK, J. POTOČKOVÁ, R. TROJANEC, J. VRBKOVÁ, J. ŠKARDA, T. BOHANES, M. SZKORUPA, B. TOLMACI, J. KLEIN, J. SROVNAL, M. HAJDÚCH
Clinical and prognostic significance of detecting CEA, EGFR, LunX, c-met and EpCAM mRNA-positive cells in the peripheral blood, tumor-draining blood and bone marrow of non-small cell lung cancer patients. Translational Lung Cancer Research. 2023, 12(5), 1034-1050, ISSN: 2226-4477 , PMID: 37323172,

Books & book chapters

Circulating tumor cells detection, 1.vyd., Olomouc, Palacky University, 2021, 48, 375-378, Dedication: LO1304, ISBN: 978-80-244-6049-9,
BARTÁKOVÁ, K., J. SROVNAL
DNA copy number variants detection using microarray, 1.vyd., Olomouc, Palacky University, 2021, 49, 379-398, Dedication: LO1304, ISBN: 978-80-244-6049-9,
SLAVÍK, H., J. SROVNAL
MiRNA expression microarray, 1.vyd., Olomouc, Palacky University, 2021, 47, 371-374, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer (Šurinová)
  1. Published Application PCT/EP2013/057111 under WO 2013/152989 (17.10.2013)

Status: Terminated

METHOD OF DETERMINATION OF CANCER CELL DRUG SENSITIVITY TOWARDS AURORA KINASE INHIBITORS AND OVERCOMIMG THEIR RESISTANCE (Madhu)
  1. Published Application PCT/CZ2012/000123 under WO 2013/083098 (13.6.2013)
  2. Patent: EP 2788504; Granted: 21.7.2016; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy MadhusudhanHajdúch MariánDžubák PetrSrovnal JosefHrabáková, Kovářová Hana  
  3. Patent: JP 6144696; Granted: 19.5.2017; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch MariánDžubák PetrSrovnal Josef, Hrabáková, Kovářová Hana
  4. Patent: CA 2.855.921; Granted: 5.3.2019; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch MariánDžubák PetrSrovnal Josef, Hrabáková, Kovářová Hana
  5. Published Application US 2014/0336073 (13.11.2014)

Status: Terminated

Doctoral mentorship

Vidlařová Monika M.Sc.

Detection and clinical importance of circulating tumor cells in solid tumours

Stav: Probíhající od 2014.
Slavík Hanuš M.Sc.

Minimal residual disease in solid cancers

Stav: Absolvoval od 2014 do 2022.
Řehulková Alona M.D.

Prognostic and predictive factors in solid tumors

Stav: Probíhající od 2015.

Master mentorship

Kvapil Marek

Liquid colorectal cancer biopsy

Stav: Probíhající od 2023.
Ondrouch Jakub B.Sc.

miRNA expression profiling in oesophageal disease

Stav: Absolvoval od 2015 do 2015.
Bačová Zuzana M.Sc.

Gene expression profiling in hematological malignancies

Stav: Absolvoval od 2013 do 2015.

Bachelor mentorship

Tinková Eva

MirRNA expression profiling in Barrett’s oesophagus

Stav: Absolvoval od 2011 do 2015.
Hošková Kateřina

Chromosomal aberations analysis in children with autistic spectrum disorders

Stav: Absolvoval od 2016 do 2017.
Horáková Kateřina

The RNA stability and degradation in the blood tubes

Stav: Absolvoval od 2018 do 2020.

Open positions

Projekt: Diagnostics and therapy of rare diseases
Vedoucí: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 places in full-time study
Projekt: New prognostic and predictive factors in solid tumors
Vedoucí: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Souhrn: 3 places in full-time or combined form of study
Projekt: New prognostic and predictive factors in solid tumors
Vedoucí: Srovnal Josef M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: Cancer is the second leading cause of death in the western countries. Early diagnosis and targeted therapy improve the therapeutic outcome. With the emergence of new biotechnologies, diagnosis can be made early and precisely, and the knowledge of tumor molecular genetics can identify the most appropriate therapy for a particular patient. The sensitivity of modern molecular methods makes it possible to characterize the tumor properties from sites remote from the primary tumor using patient's blood. The subject of the offered study program is the identification of new prognostic and predictive biomarkers of cancer using liquid biopsies. This is particularly the analysis of circulating tumor cells (CTCs), circulating free tumor DNA (ctDNA) and circulating miRNAs. The aim of the project is to further implement a liquid biopsy concept into the diagnosis and therapy monitoring of solid tumors, especially colorectal, breast, lung and CNS tumors. These include therapy response and resistance monitoring, identifying new therapeutic targets and estimating disease prognosis. The project will provide training in widely-used, transferable techniques, including circulation tumor cells capture system, digital droplet PCR, reverse-transcription qPCR, RNA-seq, single cell analyses, xenografts models and other multi-omics methods. We are looking for candidates with a background in Molecular Biology, Medicine, Cell Biology or a related area, who are enthusiastic about investigating novel approaches in cancer diagnostic that have significant potential for public health.
Projekt: Diagnosis and treatment of rare diseases
Vedoucí: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: New prognostic and predictive factors in solid tumors
Vedoucí: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Projekt: Liquid biopsies in experimental and clinical oncology
Vedoucí: Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium