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Džubák Petr M.D., Ph.D.

Journals

KORABOINA, C., V. MADDIPATI, N. ANNADURAI, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, V. DAS, R. GUNDLA
Synthesis and Biological Evaluation of Oxindole Sulfonamide Derivatives as Bruton's Tyrosine Kinase Inhibitors. ChemMedChem. 2023, ISSN: 1860-7179, PMID: 37916435,
SKOPELIDOU, V., P. HURNIK, L. TULINSKY, V. ŽIDLÍK, J. LENZ, P. DELONGOVA, H. HORNYCHOVA, P. FLODR, T. JELINEK, L. MURONOVA, D. HOLUB, P. DŽUBÁK, M. HAJDÚCH
A unique case of AH-dominant type nodular pulmonary amyloidosis presenting as a spontaneous pneumothorax: a case report and review of the literature. Pathology & Oncology Research . 2023, 29, 1611390, ISSN: 1219-4956 , PMID: 37808084,  PDF.
Nucleoside-based anticancer drugs: mechanism of action and drug resistance. Biochemical Pharmacology. 2023, ISSN: 0006-2952 , PMID: 37567317,  PDF.

Books & book chapters

Detection and quantification of cellular antigens using flow cytometry, 1.vyd., Olomouc, Palacky University, 2021, 28, 209-214, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Hmotnostní spektrometrie, 1. vyd, korigovaný dotisk, Olomouc, Univerzita Palackého v Olomouci, 2021, 2.2, 34-42, ISBN: 978-80-244-3951-8,

Intellectual property

CARBONIC ANHYDRASE INHIBITORS AND METHOD OF THEIR PRODUCTION (Řezáčová)
  1. Published Application PV 2011-676 (2.5.2013)
  2. Published Application PCT/CZ2012/000106 under WO 2013/060307 (2.5.2013)
  3. Patent: EP 2771015; Granted: 16.3.2016; Ownership: Institute of Organic Chemistry and Biochemistry CAS, Institute of Molecular Genetics CAS, Institute of Inorganic Chemistry CAS, Palacky University Olomouc; Inventors: Brynda Jiří, Cígler Petr, Gruner Bohumír, Maloy Řezáčová Pavlína, Mader Pavel, Šícha Václav, Bakardijev Mario, Džubák PetrHajdúch Marián
  4. Patent: US 9,290,529; Granted: 22.3.2016; Ownership: Institute of Organic Chemistry and Biochemistry CAS, Institute of Molecular Genetics CAS, Institute of Inorganic Chemistry CAS, Palacky University Olomouc; Inventors: Brynda Jiří, Cígler Petr, Gruner Bohumír, Maloy Řezáčová Pavlína, Mader Pavel, Šícha Václav, Bakardijev Mario, Džubák PetrHajdúch Marián

Status: Terminated

BIOAVAILABLE DITHIOCARBAMATE-METAL COMPLEX NANOPARTICLES, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM I" (Škrott)
  1. Patent: EP 3459526. Granted: 24.2.2021. Ownership: Palacky University, Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  2. Published Application PCT/EP2018/076098 under WO 2019/063601 (4.4.2019)
  3. Patent: AU 2018340510. Granted: 5.8.2021. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch MariánBártek JiříDžubák PetrZbořil Radek.
  4. Patent: CA 3,076,855. Granted: 26.4.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  5. Patent: KR 10-2456683. Granted: 14.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  6. Patent: JP 2020-537873. Granted: 29.9.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  7. Patent: MX 396,552. Granted: 17.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.

Status: Available

DIOXOCYCLOBUTENYL HYDRAZONES AND THEIR ANTICANCER ACTIVITY (Kaplánek)
  1. Patent: CZ 305626; Granted: 2.12.2015; Ownership: Institute of Chemical Technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS; Inventors: Havlík Martin, Kaplánek Robert, Dolenský Bohumil, Rak Jakub, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Terminated

Postdoctoral mentorship

Znojek Pawel Ph.D.

HCT/HCA assays development

Stav: Probíhající od 2013 do 2015.

Doctoral mentorship

Ječmeňová Kateřina

Drug resistance mechanisms in cancer

Stav: Probíhající od 2020.
Kotulová Jana Ph.D.

Identification of adenosine receptor modulators and their anticancer properties

Stav: Absolvoval od 2014 do 2022.
Stanková Jarmila

Cytotoxic drugs molecular target identification by methods of cell biology and proteomics

Stav: Probíhající od 2016.

Master mentorship

Ječmeňová Kateřina

Development and characterization of resistant cell lines to purine and pyrimidine cytotoxic drugs

Stav: Absolvoval od 2018 do 2020.
Růžičková Eliška B.Sc.

Evaluation of biological activity of demethylation drugs

Stav: Absolvoval od 2013 do 2014.
Pastorková Barbora B.Sc.

Identification of molecular targets of anticancer drugs by immuno-affinity purification

Stav: Absolvoval od 2013 do 2014.

Bachelor mentorship

Lónová Kateřina

Development and basic characterization of the cell line resistant to the CDK inhibitors

Stav: Absolvoval od 2015 do 2016.

Open positions

Projekt: Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 places in full-time study
Projekt: Antitumor drugs targeting nucleic acid metabolism
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 places in full-time study
Projekt: Identification of molecular targets and mechanisms of resistance in antitumor drugs using cell biology and proteomics methods
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 places in full-time study
Projekt: Genetic and epigenetic biomarkers of cancer diseases
Vedoucí: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Souhrn: 3 places in full-time study
Projekt: Identification of proteomic biomarkers in exhaled breath condensate in patients with systemic or pulmonary disease
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: Ph.D. topic is focused on the identification of biomarkers of lung diseases by means of a non-invasive collection of exhaled breath condensate. The project will monitor the presence of proteins in exhaled air in various diseases such as asthma, cystic fibrosis, lung tumors, or some infectious diseases, as well as quantitative changes of these proteins compared to a healthy population. Changes in these potential biomarkers with respect to therapeutic response and disease progression will be evaluated and validated.
Projekt: Identification of molecular targets of anticancer therapy applying cell biology and proteomics tools
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: Selected, highly active derivatives of triterpenes, chelators and nucleosides will be studied with a view to identify the mechanisms of their antitumor effects. Advanced methods of cell biology, proteomics and genomics such as affinity purification of protein targets, CETSA and others will be used for their study. The identified targets will be validated in relation to their clinical relevance in anticancer therapy.
Projekt: Drug resistance mechanisms in cancer
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: Mechanisms of tumor cell resistance to newly developed and existing nucleoside analog cytostatics will be studied. These drugs are used in most anti-cancer therapy protocols and the emergence of drug resistance is a major problem in the treatment of cancer patients. Resistant cell lines prepared in the past will be studied to identify the key mechanisms of resistance, which will be carried out by their detailed characterization using cell biology, but also proteomics and molecular genetics. The significance of the identified changes will be further verified on clinical material and will be applied in the development of new anticancer drugs from this class.
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium
Projekt: Genetic and epigenetic biomarkers in health and disease
Vedoucí: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium
Projekt: Identification of molecular targets and resistance mechanisms of anticancer drugs by cell biology and proteomics methods
Vedoucí: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Identification of proteomic biomarkers in proximal fluids and tissues
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Innovative approaches to protein interaction modifiers
Vedoucí: Džubák Petr M.D., Ph.D., Václavková Jana M.Sc.
K dispozici: 1
Určeno pro: Doktorské studium
Projekt: Utilization of the space of unprecedented covalent inhibitors
Vedoucí: Džubák Petr M.D., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Projekt: Anticancer drugs targeting nucleic acid metabolism
Vedoucí: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium