Urban Milan Ph.D.

Journals

BACHOŘÍK, J., I. FRYDRYCH, S. GURSKÁ, S. DOSTAL, J. POKORNÝ, M. HAJDÚCH, M. URBAN
New Synthetic Approach to C‑30 Ethers, Esters, and Amines of Betulin Using the Mitsunobu Reaction and Biological Evaluation of the Products. ACS Omega. 2026, 11(16), 24564-24579, ISSN: 2470-1343, PMID: 42077890,  PDF.
KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells – Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761,  PDF.
BORKOVÁ, L., I. FRYDRYCH, B. VRÁNOVÁ, N. JAKUBCOVÁ, B. LIŠKOVÁ, P. DŽUBÁK, P. PAVLIŠ, M. HAJDÚCH, M. URBAN
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,

Books & book chapters

DŽUBÁK, P., M. URBAN, M. HAJDÚCH
Vývoj nových léčiv, 1. vyd, Praha, Galén, 2015, 11, 469-472, ISBN: 978-80-7492-121-6,
URBAN, M., M. KVASNICA, N. DICKINSON, J. ŠAREK
Biologically Active Triterpenoids Usable As Prodrugs, 1. vyd, New York, USA, Nova Science Publishers, 2015, 2, 25-50, Dedication: CZ.1.05/2.1.00/01.0030, ISBN: 978-1-63463-656-8,
ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK, M. HAJDÚCH
The Potential of Triterpenoids in the Treatment of Melanoma, 1.vyd, Rijeka, InTech, 2011, 7, 125-158, Dedication: 305/09/1216, ISBN: 978-953-307-293-7,

Intellectual property

C-28 BIOTINYLATED HETEROCYCLIC TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307 165; Granted: 3.1.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan

​Status: Terminated 

C-3 BIOTINYLATED TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307227; Granted: 28.2.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan

​Status: Terminated

TERPENOID DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION (Urban)
  1. Published Application: PV 2020-651 (15.6.2022). Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav. Ownership: Palacký University Olomouc.
  2. Published Application: PCT/CZ2021/050146 under WO 2022/117133 (9.6.2022). Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav. Ownership: Palacký University Olomouc.

 Status: Patent pending; Available 

Doctoral mentorship

Bachořík Jan

Preparation of semisynthetic triterpenes

Stav: Probíhající od 2019.
Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Stav: Probíhající od 2022 do 2022.
Jurčeka Ondřej

Modification of lupine triterpenes in position C-17

Stav: Probíhající od 2022.

Master mentorship

Maršálková Natálie

Preparation of new cytotoxic betulin ester derivatives

Stav: Probíhající.
Horka Vladimír

Conjugates of betulin prepared by cycloaddition reactions

Stav: Absolvoval od 2018 do 2020.
Pisár Martin

Preparation of semisynthetic derivatives of betulinic acid with cytotoxic activity

Stav: Absolvoval od 2017 do 2019.

Bachelor mentorship

Zamazal Viktor

Preparation of new triterpene derivatives based on sulfur

Stav: Probíhající od 2022.
Jarošová Amálie

Preparation of new nitrogen-based triterpene derivatives

Stav: Probíhající od 2022.
Oriešková Eliška

Preparation of new triterpene derivatives based on peptides

Stav: Probíhající od 2022.

Open positions

Projekt: Modifications of biologically active molecules leading to improvement of their pharmacological properties
Vedoucí: Urban Milan Ph.D., Ranc Václav Ph.D., Polishchuk Pavlo Ph.D., M.Sc.
K dispozici: 3
Určeno pro: Doktorské studium
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium