Jakubcová Nikola
Academic title:
Mgr.
E-mail:
nikola.jakubcova@upol.cz
Phone:
+ 420 585 632 183
Groups:
CHEMISTRY, IMTM, MEDCHEM, STAFF
About me
In our research, we focus on the preparation of semi-synthetic derivatives of triterpenes with the aim of improving their biological properties. I am currently focusing on the preparation of heterocyclic derivatives of triterpenic acids with potential cytotoxic activity.
Journals
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes.
European Journal of Medicinal Chemistry.
2022,
244,
114850,
ISSN: 0223-5234,
PMID: 36283179,
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid.
European Journal of Medicinal Chemistry.
2019,
185,
111806,
ISSN: 0223-5234,
PMID: 31677446,