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Slavkovský Rastislav Ph.D.

Journals

PLEVOVA, P., J. INDRAKOVA, J. SAVIGE, P. KUHNOVA, P. TVRDA, D. CERNA, S. HILSCHEROVA, M. KUDREJOVA, D. POLENDOVA, R. JAKLOVA, M. LANGOVA, H. JAHNOVA, J. LASTUVKOVA, J. DUSEK, J. GUT, M. VLCKOVA, P. SOLAROVA, G. KRECKOVA, E. KANTOROVA, J. SOUKALOVA, R. SLAVKOVSKÝ, J. ZAPLETALOVÁ, T. TICHÝ, D. THOMASOVA
A founder COL4A4 pathogenic variant resulting in autosomal recessive Alport syndrome accounts for most genetic kidney failure in Romani people. Frontiers in Medicine. 2023, 10, 1096869, ISSN: 2296-858X, PMID: 36844206,  PDF.
Evaluation of Non-Invasive Gargle Lavage Sampling for the Detection of SARS-CoV-2 Using rRT-PCR or Antigen Assay. Viruses. 2022, 14(12), 2829, ISSN: 1999-4915, PMID: 36560833,  PDF.
SLAVÍK, H., V. BALIK, F. KOKAS, R. SLAVKOVSKÝ, J. VRBKOVÁ, A. ŘEHULKOVÁ, T. LAUSOVÁ, J. EHRMANN, S. GURSKÁ, I. ÜBERALL, M. HAJDÚCH, J. SROVNAL
Transcriptomic Profiling Revealed Lnc-GOLGA6A-1 as a Novel Prognostic Biomarker of Meningioma Recurrence. Neurosurgery. 2022, 91(2), 360-369, ISSN: 0148-396X, PMID: 35551164,

Books & book chapters

Bisulfite amplicon next-generation sequencing for methylation status assessment , 1.vyd., Olomouc, Palacky University, 2021, 51, 409-422, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Doctoral mentorship

Kalousová Barbora M.Sc.

Genetic biomarkers of tumors and aging

Stav: Probíhající od 2019.

Master mentorship

Zermeghová Denisa

Development of new diagnostic solutions for genotyping the tumor marker BCR-ABL1

Stav: Probíhající od 2022.
Věnsková Veronika

Diagnostics of mutations in RAS family oncogenes in tumors using next-generation sequencing

Stav: Absolvoval od 2014 do 2016.
Fryčová Gabriela

Methylome profiling in cancer cells for identification of bevacizumab response biomarkers

Stav: Absolvoval od 2016 do 2018.

Bachelor mentorship

Zermeghová Denisa

Development of new diagnostic solutions for genotyping the tumor marker BCR-ABL1

Stav: Absolvoval od 2021 do 2022.
Fryčová Gabriela

Methylome profile changes in cancer cells associated with drug resistance

Stav: Absolvoval od 2013 do 2016.
Vysloužilová Lenka

High-throughput sequencing and its use for identifying inherited causes of cardiomyopathies

Stav: Absolvoval od 2013 do 2016.

Open positions

Projekt: Genetic and epigenetic biomarkers of cancer diseases
Vedoucí: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Souhrn: 3 places in full-time study
Projekt: Genetic and epigenetic biomarkers in cancer
Vedoucí: Drábek Jiří Ph.D., Slavkovský Rastislav Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Souhrn: Clonal hematopoiesis of indeterminate potential (CHIP) has recently been described as a common phenomenon associated with aging. It is characterized by the accumulation of somatic mutations in cells of the hematopoietic system. Although CHIP is manifested by the expansion of certain cell clones, this condition is not accompanied by any morphological features of hematological neoplasia. However, it has been shown that the incidence of clonal hematopoiesis correlates with increased overall mortality and the risk of developing malignant transformation of hematopoietic cells as well as cardiovascular disease, such as ischemic stroke. To what extent and by what mechanisms clonal hematopoiesis contributes to disease development remains a question of current research. The main aim of the project will be to pinpoint the principal cells carrying CHIP somatic mutations, and to study their role in development and maintenance of atherosclerotic plaques, especially of those involved in development of stroke. The comparison of the phenotype of CHIP positive and negative cells will be of special interest. The use of cellular models not only include different types of leucocytes but circulatory progenitor endothelial cells as well. The study will involve elderly subjects with the positive presence of CHIP (>65 years). Subject will be characterized based on the presence or absence of ischemic stroke and the presence or absence of carotid stenosis by our clinical collaborators. The presence of somatic variants in 38 selected genes associated with CHIP will be tested in subjects of interest within our research group. The project will use various techiques including FACS, MACS, cell cultures, DNA isolation from small amount of cells, a highly sensitive sequencing method for DNA genotyping allowing detection of variant with less than 1% allelic frequency, DNA/RNA sequencing library preparation, deep massively parallel sequencing of panel of genes using unique molecular barcodes/indices, RNAseq, bioinformatics and data analysis with possibilities of calculations using high performance computing cluster, data management and statistical evaluation.
Projekt: Genetic and epigenetic biomarkers in health and disease
Vedoucí: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium