Das Viswanath M.Sc., Ph.D.
Journals
Antitumour drugs targeting tau R3 VQIVYK and Cys322 prevent seeding of endogenous tau aggregates by exogenous seeds.
FEBS Journal.
2021,
289(7),
1929-1949,
ISSN: 1742-464X,
PMID: 34743390,
Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies.
Experimental Neurology.
2021,
343,
113756,
ISSN: 0014-4886,
PMID: 33989658,
Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds.
Chembiochem : a European Journal of Chemical Biology.
2021,
22(18),
2741-2761,
ISSN: 1439-4227,
PMID: 33939874,
Master mentorship
Open positions
Projekt: | The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 1 |
Určeno pro: | Doktorské studium |
Souhrn: | 1 place in full-time study |
Projekt: | A combination of 2D and 3D cell cultures for a smart and effective identification and characterization of anti-hypoxic candidates |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 1 |
Určeno pro: | Doktorské studium |
Souhrn: | Hypoxia is a prominent feature of different solid tumor types. A central component of hypoxic adaptation is the stabilization of hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator of hypoxia that orchestrates the transcriptional regulation of genes involved in a plethora of cellular processes. Considering the multiple roles of HIF-1 in cancer, interest in novel small-molecule inhibitors of the HIF-1 pathway has steadily increased over the past 10 years. However, despite extensive research, no specific inhibitor of HIF-1 has been brought to the market, making the field still ripe for further exploration. The goal of the present work is to utilize the potential of a combination of 2D and 3D cellular models for identification and characterization of inhibitors of HIF-1 and/or HIF-1 pathway by screening in 2D cultures, and lightsheet microscopy and mass spectrometry studies in spheroid cultures. |
Projekt: | An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 1 |
Určeno pro: | Doktorské studium |
Souhrn: | An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies |
Projekt: | The role of tumor hypoxia in the acquisition of resistance to microtubule-targeting drugs |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 1 |
Určeno pro: | Doktorské studium |
Souhrn: | Hypoxia is one of the major factors causing resistance to microtubule-stabilizing drugs (MSDs) and other non-microtubule drugs used in chemotherapy. Hypoxia results in changes in tubulin conformation, expression of tubulin isotypes and metabolic pathways that make cancer cells less susceptible to paclitaxel, a taxane used extensively in the treatment of solid tumors. Recent cellular studies have shown that non-taxane MSDs with a similar mode of microtubule stabilization to paclitaxel is more effective in hypoxic cancer cells than paclitaxel. Due to a different microtubule-binding site, we hypothesize that non-taxane MSDs may have a better cytotoxic effect in cancer cells under hypoxia. The goal of this project is to study the anti-cancer effect of non-taxane MSDs in hypoxic ovarian and cervical cancer cell models. |
Projekt: | Systems approaches to understanding aging and neurodegeneration |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 2 |
Určeno pro: | Doktorské studium |
Projekt: | The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 1 |
Určeno pro: | Doktorské studium |
Projekt: | Research and development of agents for cancer, neurodegenerative and infectious diseases |
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Vedoucí: | De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D. |
K dispozici: | 5 |
Určeno pro: | Doktorské studium |
Projekt: | Role of axonal transport and pathology in neurodegeneration |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 2 |
Určeno pro: | Doktorské studium |
Projekt: | Development of organoid assays for anti-tumour drug screening |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 2 |
Určeno pro: | Bakalářské studium |
Projekt: | Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 2 |
Určeno pro: | Bakalářské studium |
Projekt: | Drug synergy studies in 3D spheroids cultures of tumour cell lines |
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Vedoucí: | Das Viswanath M.Sc., Ph.D. |
K dispozici: | 2 |
Určeno pro: | Bakalářské studium |