Medicinal chemistry and bioactive natural products

Laboratory of Medicinal and Organic Chemistry
Senior research group

Our research group is currently focused on natural triterpenoids and their semi-synthetic analogues and on the studies of their biological activities. Based on the activities, we have two main domains of research.

  1. Compounds with anti-cancer activity
  2. Compounds with neuroprotective activity
  • Modifications of the position C-30 in lupane triterpenoids
  • Triterpenoids with condensed heterocycle to the main skeleton
  • Fluorescently labelled triterpenoids and their visualization in the living environment
  • Bioorthogonal click-reaction of selectively cytotoxic triterpenes
  • Development of compounds selectively cytotoxic in resistant cancer cells
  • Compounds labelled with deuterium and their visualization using Raman confocal microscopy
  • Natural products with neuroprotective properties and elucitation of their mechanism of action
BORKOVÁ, L., I. FRYDRYCH, N. JAKUBCOVÁ, R. ADÁMEK, B. LIŠKOVÁ, S. GURSKÁ, M. MEDVEDÍKOVÁ, M. HAJDÚCH, M. URBAN
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. European Journal of Medicinal Chemistry. 2019, 185, 111806, ISSN: 0223-5234, PMID: 31677446,
BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN, J. ŠAREK
Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398, ISSN: 1860-7179, PMID: 28084676,

Group leader

Group members

CHEMIE, ÚMTM, MEDCHEM, PERSONÁL
CHEMIE, ÚMTM, MEDCHEM, PERSONÁL
MEDCHEM, MAGISTERSKÝ STUDENT, BAKALÁŘSKÝ STUDENT
ÚMTM, LEM, PERSONÁL, VEDOUCÍ