Přejít k hlavnímu obsahu

Lišková Barbora Ph.D.

Journals

VESELOVSKA, L., N. KUDLOVÁ, S. GURSKÁ, B. LIŠKOVÁ, M. MEDVEDÍKOVÁ, O. HODEK, E. TLOUŠŤOVÁ, N. MILISAVLJEVIC, M. TICHÝ, P. PERLÍKOVÁ, H. MERTLIKOVA-KAISEROVA, J. TRYLCOVA, R. POHL, B. KLEPETAROVA, P. DŽUBÁK, M. HAJDÚCH, M. HOCEK
Synthesis and Cytotoxic and Antiviral Activity Profiling of All-Four Isomeric Series of Pyrido-Fused 7-Deazapurine Ribonucleosides. Chemistry. 2020, 26(57), 13002-13015, ISSN: 0947-6539, PMID: 32275109,
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. European Journal of Medicinal Chemistry. 2019, 185, 111806, ISSN: 0223-5234, PMID: 31677446,
GRUNER, B., J. BRYNDA, V. DAS, V. SICHA, J. ŠTĚPÁNKOVÁ, J. NEKVINDA, J. HOLUB, K. POSPISILOVA, M. FABRY, P. PACHL, V. KRAL, M. KUGLER, V. MAŠEK, M. MEDVEDÍKOVÁ, S. MATEJKOVA, A. NOVÁ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, P. ŘEZÁČOVÁ
Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX. Journal of Medicinal Chemistry. 2019, 62(21), 9560-9575, ISSN: 0022-2623, PMID: 31568723,

Open positions

Projekt: Pharmacokinetic methods in preclinical drug testing
Vedoucí: Hajdúch Marián M.D., Ph.D., Lišková Barbora Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: The study of ADME properties of a potential drug that are part of the IMTM chemical library - obtained by national or international cooperation belongs to one of the first steps in predicting potential drugs. In vitro models generate many ADME parameters, including chemical, plasma and microsomal stability, plasma protein binding and proportion of passive diffusion as a transport mechanism. The Caco-2 and MDCK-MDR1 permeability assays are established models of intestinal and blood-brain barriers, respectively. Analysis of samples is performed using a Agilent RapidFire 300 - rapid online solid phase extraction with subsequent detection of the mass spectrometer Qtrap 5500 (AB Sciex) - RF/MS. High-Throughput Mass Spectrometry System RF/MS delivers ultrafast, label – free analysis of native compounds for biochemical assays in ADME and provide throughput speeds of 6 to 10 seconds per sample.
Projekt: Study of basic pharmacokinetic properties (ADME) of new drugs in preclinical development
Vedoucí: Lišková Barbora Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium