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Skupiny: ÚMTM, LEM, METABOLOMIKA, PERSONÁL, VEDOUCÍ

O mně

My area of research was always within the grasp of the metabolomics field. After I studied biochemistry, I have been working at the University Hospital Olomouc and my PhD was focused on medical genetics – especially in the potential application of untargeted metabolomics tools in clinical practice as a diagnostic tool. During my first internship at the University of Barcelona (Barcelona, Spain) I have learnt how to work with cell cultures and various techniques in molecular biology. During my second internship in San Jose (CA, USA) at Thermo Fisher Scientific, I got advanced skills and training in Orbitrap-based mass spectrometers and software. I see the metabolomics great potential as a ‘universal’ diagnostic tool in personalised medicine. In my opinion, the first signs can already be seen e.g. as use of the iKnife or in the improvement in new-born screening across the world. As a part of a great team of the scientists of Phenome Centre Birmingham, I was able to participate in many projects which helped me to get deeper insights in cooperation between academia and commercial subjects (industry). Now I have returned to my alma mater to the Palacký University where I want to continue my research. In future, I would like to focus my efforts on the study of the oxidative stress on the metabolite level. I would like to transfer more of lipidomics research into clinical practice. In my opinion, lipidomics approach has a great diagnostic potential for clinicians and there are still many undiscovered research opportunities.

Journals

ALIMAJSTOROVIC, Z., S. MOLLAN, O. GRECH, J. MITCHELL, A. YIANGOU, M. THALLER, H. LYONS, M. SASSANI, S. SENEVIRATNE, T. HANCOX, A. JANKEVICS, L. NAJDEKR, W. DUNN, A. SINCLAIR
Dysregulation of Amino Acid, Lipid, and Acylpyruvate Metabolism in Idiopathic Intracranial Hypertension: A Non-targeted Case Control and Longitudinal Metabolomic Study. Journal of Proteome Research. 2022, 22(4), 1127-1137, ISSN: 1535-3893, PMID: 36534069,
PURIS, E., Š. KOUŘIL, L. NAJDEKR, S. AURIOLA, S. LOPPI, P. KORHONEN, M. GOMEZ-BUDIA, G. FRICKER, K. KANNINEN, T. MALM, D. FRIEDECKÝ, M. GYNTHER
Metabolomic, lipidomic and proteomic characterisation of lipopolysaccharide-induced inflammation mouse model. Neuroscience. 2022, 496, 165-178, ISSN: 0306-4522, PMID: 35636730,  PDF.
KVASNIČKA, A., D. FRIEDECKÝ, A. TICHA, R. HYSPLER, H. JANEČKOVÁ, R. BRUMAROVÁ, L. NAJDEKR, Z. ZADAK
SLIDE-Novel Approach to Apocrine Sweat Sampling for Lipid Profiling in Healthy Individuals. International Journal of Molecular Sciences. 2022, 22(15), 8054, ISSN: 1422-0067, PMID: 34360820,  PDF.

Master mentorship

Pokorná Natálie

Development and validation of LC/MS assay for analyses of fat-soluble vitamins

Stav: Absolvoval od 2021 do 2023.

Bachelor mentorship

Machálková Markéta

Untargeted metabolomics of T-lymphoblastic leukemia cells affected by quinolinone derivative

Stav: Absolvoval od 2011 do 2013.

Šťastná Veronika

Metabolomic analysis of mouse plasma using aminopropyl column and TripleQ-MS

Stav: Absolvoval od 2011 do 2013.

Mádrová Lucie M.Sc

Analysis of lipids in blood stains for the diagnosis of inherited metabolic disorders

Stav: Absolvoval od 2011 do 2013.

Volná místa

2 Molecular and Translational Medicine
Projekt: Use of open-source software approaches for analysis of metabolomic and lipidomic clinical data
Vedoucí: Najdekr Lukáš Ph.D.
K dispozici: 1
Určeno pro: Doctoral training
Projekt: Isolation and analysis of membrane lipid rafts using a non-targeted metabolomics and lipidomics approach
Vedoucí: Najdekr Lukáš Ph.D.
K dispozici: 1
Určeno pro: Doctoral training