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Skupiny: ÚMTM, LEM, METABOLOMIKA, PERSONÁL, VEDOUCÍ

O mně

My area of research was always within the grasp of the metabolomics field. After I studied biochemistry, I have been working at the University Hospital Olomouc and my PhD was focused on medical genetics – especially in the potential application of untargeted metabolomics tools in clinical practice as a diagnostic tool. During my first internship at the University of Barcelona (Barcelona, Spain) I have learnt how to work with cell cultures and various techniques in molecular biology. During my second internship in San Jose (CA, USA) at Thermo Fisher Scientific, I got advanced skills and training in Orbitrap-based mass spectrometers and software. I see the metabolomics great potential as a ‘universal’ diagnostic tool in personalised medicine. In my opinion, the first signs can already be seen e.g. as use of the iKnife or in the improvement in new-born screening across the world. As a part of a great team of the scientists of Phenome Centre Birmingham, I was able to participate in many projects which helped me to get deeper insights in cooperation between academia and commercial subjects (industry). Now I have returned to my alma mater to the Palacký University where I want to continue my research. In future, I would like to focus my efforts on the study of the oxidative stress on the metabolite level. I would like to transfer more of lipidomics research into clinical practice. In my opinion, lipidomics approach has a great diagnostic potential for clinicians and there are still many undiscovered research opportunities.

Journals

GIEBELHAUS, R., M. HEROLD, J. HARYNUK, D. ALONSO, B. AMER, C. BROECKLING, P. CHARISIADIS, R. CUMERAS, A. DE LA MATA, W. DUNN, F. FRANCHINA, H. GIKA, J. KIRWAN, I. MUTI, L. NAJDEKR, E. PUJOS-GUILLOT, P. STEFANUTO, T. STEININGER-MAIRINGER, A. THAKKER, O. FIEHN
Best Practices in GC-MS and GC × GC-MS-Based Metabolomics and Volatile Analyses: An International Survey. Analytical Chemistry. 2026, ISSN: 0003-2700, PMID: 42030522,  PDF.
BEGER, R., R. GOODACRE, C. JONES, K. LIPPA, O. MAYBORODA, D. O´NEILL, L. NAJDEKR, I. NTAI, I. WILSON, W. DUNN
Analysis types and quantification methods applied in UHPLC-MS metabolomics research: a tutorial. Metabolomics. 2024, 20(5), 95, ISSN: 1573-3882, PMID: 39110307,  PDF.
Clinical lipidomics in the era of the big data. Clinical Chemistry and Laboratory Medicine. 2023, 61(4), 587-598, ISSN: 1434-6621, PMID: 36592414,

Doctoral mentorship

Macháň Jan

Application of open-source software approaches for analyses of clinical metabolmics and lipidomics data

Stav: Probíhající od 2023.

Master mentorship

Mádrová Lucie M.Sc

Usage of lipid profile for study of inherited metabolic disorders

Stav: Absolvoval od 2013 do 2015.

Filipová Sára

Metabolomic characterisation of endometriosis

Stav: Ongoing od 2023.

Masař Richard

Lipidomic profiling of cardiovascular disease

Stav: Probíhající od 2021.

Bachelor mentorship

Boyko Daniel

Targeted metabolomics of transgenic mice suffering from LPS-induced neuroinflammation

Stav: Absolvoval od 2017 do 2018.

Filipová Sára

Analysis of omega-3 fatty acid from fish extracts

Stav: Absolvoval od 2021 do 2023.

Masař Richard

Development and validation of LC/MS assay for analyses of fat-soluble vitamins

Stav: Absolvoval od 2021 do 2022.

Volná místa

2 Molecular and Translational Medicine
Projekt: Use of open-source software approaches for analysis of metabolomic and lipidomic clinical data
Vedoucí: Najdekr Lukáš Ph.D.
K dispozici: 1
Určeno pro: Doctoral training
Projekt: Isolation and analysis of membrane lipid rafts using a non-targeted metabolomics and lipidomics approach
Vedoucí: Najdekr Lukáš Ph.D.
K dispozici: 1
Určeno pro: Doctoral training