Mistrík Martin Ph.D.

Journals

JORDA, R., L. HAVLICEK, I. MCNAE, M. WALKINSHAW, J. VOLLER, A. STURC, J. NAVRATILOVA, M. KUZMA, M. MISTRÍK, J. BÁRTEK, M. STRNAD, V. KRYŠTOF
Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity. Journal of Medicinal Chemistry. 2011, 54(8), 2980-2993, ISSN: 0022-2623, PMID: 21417417,
LÖFFLER, H., A. FECHTER, M. MATUSZEWSKA, R. SAFFRICH, M. MISTRÍK, J. MARHOLD, C. HORNUNG, F. WESTERMANN, J. BÁRTEK, A. KRÄMER
Cep63 Recruits Cdk1 to the Centrosome: Implications for Regulation of Mitotic Entry, Centrosome Amplification, and Genome Maintenance. Cancer Research. 2011, 71(6), 2129-2139, ISSN: 0008-5472, PMID: 21406398,
BÁRTEK, J., M. MISTRÍK, J. BARTKOVA
Long-distance inflammatory and genotoxic impact of cancer in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2010, 107(42), 17861-17862, ISSN: 0027-8424, PMID: 20926747,

Open positions

Projekt: DNA damage signaling in the cellular response to stress
Vedoucí: Mistrík Martin Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 place in full-time study
Projekt: Signaling DNA damage in cellular response to stress
Vedoucí: Mistrík Martin Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: Our DNA is constantly under threat from DNA damaging agents. If unrepaired DNA damage can lead to errors during genome duplication, including the mutations that can lead to cancer, contribute to aging and other human diseases. Cells have evolved elaborate repair mechanisms to fix this damage and ensure that the genetic information is faithfully reproduced, and we would like to understand these repair mechanisms at the molecular level. We ultimately aim for a complete molecular and cellular understanding of critical DNA repair pathways that act on DNA damage. The Ph.D. student will practice several molecular and cellular techniques, including cell culture, RNA interference, immunofluorescence microscopy, live-cell imaging and immunoprecipitation of proteins. He/she will also learn novel and powerful techniques, such as super-resolution microscopy and purification of proteins on newly synthesized DNA.
Projekt: Study of DNA double-strand break repair in tumor model
Vedoucí: Mistrík Martin Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: The so-called double-strand breaks (DSB) are the most lethal DNA lesions, which can be potent sources of mutations and thus become the beginning of irreversible genetic changes leading to degenerative illnesses, including cancer. At the same induction of DSBs introduced in the proper setup can become an unsolvable problem for the cells, particularly in specific genetic backgrounds typical for cancer, which fact is the rationale for a plethora of cancer treatment strategies. Thus the way cells deal with DSBs is under the great interest of current medicinal and biological research. The Ph.D. student will practice several methods of induction of DSBs via various sources such as gamma rays, alpha particles, UV light and various chemical inducers. Next will be studied the molecular mechanisms the cell deal with this type of DNA damage. Emphasis will be put on differences between normal and cancer cells and their potential exploration for cancer therapy. Student will also learn mutiple laboratory techniques including cell culture, RNA/DNA transfections, advanced microscopic techniques, live-cell imaging, and various biochemical analysis of proteins.
Projekt: Cellular stress in health and disease
Vedoucí: Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Projekt: DNA damage signaling in the cellular response to stress
Vedoucí: Mistrík Martin Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium