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Džubák Petr M.D., Ph.D.

Journals

SCHADICH, E., A. KRYSHCHYSHYN-DYLEVYCH, S. HOLOTA, P. POLISHCHUK, P. DŽUBÁK, S. GURSKÁ, M. HAJDÚCH, R. LESYK
Assessing different thiazolidine and thiazole based compounds as antileishmanial scaffolds. Bioorganic & Medicinal Chemistry Letters. 2020, 30(23), 127616, ISSN: 0960-894X, PMID: 33091607,
FLEUTI, M., K. BARTOVA, L. POSTOVA SLAVETINSKA, E. TLOUŠŤOVÁ, M. TICHÝ, S. GURSKÁ, P. PAVLIŠ, P. DŽUBÁK, M. HAJDÚCH, M. HOCEK
Synthesis and Biological Profiling of Pyrazolo-Fused 7-Deazapurine Nucleosides. The Journal of Organic Chemistry. 2020, 85(16), 10539-10551, ISSN: 0022-3263, PMID: 32692916,
DVOŘANOVÁ ŠTĚPÁNKOVÁ, J., M. KUGLER, J. HOLUB, V. SICHA, V. DAS, J. NEKVINDA, S. EL ANWAR, M. HAVRANEK, K. POSPISILOVA, M. FABRY, V. KRAL, M. MEDVEDÍKOVÁ, S. MATEJKOVA, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, J. BRYNDA, M. HAJDÚCH, B. GRUNER, P. ŘEZÁČOVÁ
Sulfonamido Carboranes as Highly Selective Inhibitors of Cancer-Specific Carbonic Anhydrase IX. European Journal of Medicinal Chemistry. 2020, 200, 112460, ISSN: 0223-5234, PMID: 32505851,

Open positions

Projekt: Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 places in full-time study
Projekt: Antitumor drugs targeting nucleic acid metabolism
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 places in full-time study
Projekt: Identification of molecular targets and mechanisms of resistance in antitumor drugs using cell biology and proteomics methods
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 places in full-time study
Projekt: Genetic and epigenetic biomarkers of cancer diseases
Vedoucí: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 3
Určeno pro: Doktorské studium
Souhrn: 3 places in full-time study
Projekt: Identification of proteomic biomarkers in exhaled breath condensate in patients with systemic or pulmonary disease
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: Ph.D. topic is focused on the identification of biomarkers of lung diseases by means of a non-invasive collection of exhaled breath condensate. The project will monitor the presence of proteins in exhaled air in various diseases such as asthma, cystic fibrosis, lung tumors, or some infectious diseases, as well as quantitative changes of these proteins compared to a healthy population. Changes in these potential biomarkers with respect to therapeutic response and disease progression will be evaluated and validated.
Projekt: Identification of molecular targets of anticancer therapy applying cell biology and proteomics tools
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: Selected, highly active derivatives of triterpenes, chelators and nucleosides will be studied with a view to identify the mechanisms of their antitumor effects. Advanced methods of cell biology, proteomics and genomics such as affinity purification of protein targets, CETSA and others will be used for their study. The identified targets will be validated in relation to their clinical relevance in anticancer therapy.
Projekt: Drug resistance mechanisms in cancer
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: Mechanisms of tumor cell resistance to newly developed and existing nucleoside analog cytostatics will be studied. These drugs are used in most anti-cancer therapy protocols and the emergence of drug resistance is a major problem in the treatment of cancer patients. Resistant cell lines prepared in the past will be studied to identify the key mechanisms of resistance, which will be carried out by their detailed characterization using cell biology, but also proteomics and molecular genetics. The significance of the identified changes will be further verified on clinical material and will be applied in the development of new anticancer drugs from this class.
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium
Projekt: Genetic and epigenetic biomarkers in health and disease
Vedoucí: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium
Projekt: Identification of molecular targets and resistance mechanisms of anticancer drugs by cell biology and proteomics methods
Vedoucí: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Identification of proteomic biomarkers in proximal fluids and tissues
Vedoucí: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Innovative approaches to protein interaction modifiers
Vedoucí: Džubák Petr M.D., Ph.D., Václavková Jana M.Sc.
K dispozici: 1
Určeno pro: Doktorské studium
Projekt: Utilization of the space of unprecedented covalent inhibitors
Vedoucí: Džubák Petr M.D., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Projekt: Anticancer drugs targeting nucleic acid metabolism
Vedoucí: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium