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Das Viswanath M.Sc., Ph.D.

Journals

DAS, V., J. DVOŘANOVÁ ŠTĚPÁNKOVÁ, M. HAJDÚCH, J. MILLER
Role of tumor hypoxia in acquisition of resistance to microtubule-stabilizing drugs. Biochimica et Biophysica Acta Reviews on Cancer. 2015, 1855(2), 172-182, ISSN: 0304-419X, PMID: 25662312,
DAS, V., A. KANAKKANTHARA, A. CHAN, J. MILLER
Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance. Cancer Letters. 2014, 350(1-2), 1-4, ISSN: 0304-3835, PMID: 24814394,
DAS, V., D. SIM, J. MILLER
Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture. Journal of Neuroscience Research. 2014, 92(9), 1155-1166, ISSN: 0360-4012, PMID: 24788108,

Open positions

Projekt: The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 place in full-time study
Projekt: A combination of 2D and 3D cell cultures for a smart and effective identification and characterization of anti-hypoxic candidates
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: Hypoxia is a prominent feature of different solid tumor types. A central component of hypoxic adaptation is the stabilization of hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator of hypoxia that orchestrates the transcriptional regulation of genes involved in a plethora of cellular processes. Considering the multiple roles of HIF-1 in cancer, interest in novel small-molecule inhibitors of the HIF-1 pathway has steadily increased over the past 10 years. However, despite extensive research, no specific inhibitor of HIF-1 has been brought to the market, making the field still ripe for further exploration. The goal of the present work is to utilize the potential of a combination of 2D and 3D cellular models for identification and characterization of inhibitors of HIF-1 and/or HIF-1 pathway by screening in 2D cultures, and lightsheet microscopy and mass spectrometry studies in spheroid cultures.
Projekt: An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies
Projekt: The role of tumor hypoxia in the acquisition of resistance to microtubule-targeting drugs
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: Hypoxia is one of the major factors causing resistance to microtubule-stabilizing drugs (MSDs) and other non-microtubule drugs used in chemotherapy. Hypoxia results in changes in tubulin conformation, expression of tubulin isotypes and metabolic pathways that make cancer cells less susceptible to paclitaxel, a taxane used extensively in the treatment of solid tumors. Recent cellular studies have shown that non-taxane MSDs with a similar mode of microtubule stabilization to paclitaxel is more effective in hypoxic cancer cells than paclitaxel. Due to a different microtubule-binding site, we hypothesize that non-taxane MSDs may have a better cytotoxic effect in cancer cells under hypoxia. The goal of this project is to study the anti-cancer effect of non-taxane MSDs in hypoxic ovarian and cervical cancer cell models.
Projekt: Systems approaches to understanding aging and neurodegeneration
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium
Projekt: Role of axonal transport and pathology in neurodegeneration
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Development of organoid assays for anti-tumour drug screening
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Bakalářské studium
Projekt: Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Bakalářské studium
Projekt: Drug synergy studies in 3D spheroids cultures of tumour cell lines
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Bakalářské studium