Das Viswanath M.Sc., Ph.D.
Journals
Role of tumor hypoxia in acquisition of resistance to microtubule-stabilizing drugs.
Biochimica et Biophysica Acta Reviews on Cancer.
2015,
1855(2),
172-182,
ISSN: 0304-419X,
PMID: 25662312,
Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance.
Cancer Letters.
2014,
350(1-2),
1-4,
ISSN: 0304-3835,
PMID: 24814394,
Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture.
Journal of Neuroscience Research.
2014,
92(9),
1155-1166,
ISSN: 0360-4012,
PMID: 24788108,
Open positions
Project: | The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 1 |
Intended for: | Doctoral training |
Summary: | 1 place in full-time study |
Project: | A combination of 2D and 3D cell cultures for a smart and effective identification and characterization of anti-hypoxic candidates |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 1 |
Intended for: | Doctoral training |
Summary: | Hypoxia is a prominent feature of different solid tumor types. A central component of hypoxic adaptation is the stabilization of hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator of hypoxia that orchestrates the transcriptional regulation of genes involved in a plethora of cellular processes. Considering the multiple roles of HIF-1 in cancer, interest in novel small-molecule inhibitors of the HIF-1 pathway has steadily increased over the past 10 years. However, despite extensive research, no specific inhibitor of HIF-1 has been brought to the market, making the field still ripe for further exploration. The goal of the present work is to utilize the potential of a combination of 2D and 3D cellular models for identification and characterization of inhibitors of HIF-1 and/or HIF-1 pathway by screening in 2D cultures, and lightsheet microscopy and mass spectrometry studies in spheroid cultures. |
Project: | An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 1 |
Intended for: | Doctoral training |
Summary: | An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies |
Project: | The role of tumor hypoxia in the acquisition of resistance to microtubule-targeting drugs |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 1 |
Intended for: | Doctoral training |
Summary: | Hypoxia is one of the major factors causing resistance to microtubule-stabilizing drugs (MSDs) and other non-microtubule drugs used in chemotherapy. Hypoxia results in changes in tubulin conformation, expression of tubulin isotypes and metabolic pathways that make cancer cells less susceptible to paclitaxel, a taxane used extensively in the treatment of solid tumors. Recent cellular studies have shown that non-taxane MSDs with a similar mode of microtubule stabilization to paclitaxel is more effective in hypoxic cancer cells than paclitaxel. Due to a different microtubule-binding site, we hypothesize that non-taxane MSDs may have a better cytotoxic effect in cancer cells under hypoxia. The goal of this project is to study the anti-cancer effect of non-taxane MSDs in hypoxic ovarian and cervical cancer cell models. |
Project: | Systems approaches to understanding aging and neurodegeneration |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 2 |
Intended for: | Doctoral training |
Project: | The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs |
---|---|
Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 1 |
Intended for: | Doctoral training |
Project: | Research and development of agents for cancer, neurodegenerative and infectious diseases |
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Supervisors: | De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D. |
Available: | 5 |
Intended for: | Doctoral training |
Project: | Role of axonal transport and pathology in neurodegeneration |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 2 |
Intended for: | Doctoral training |
Project: | Development of organoid assays for anti-tumour drug screening |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 2 |
Intended for: | Bachelor training |
Project: | Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 2 |
Intended for: | Bachelor training |
Project: | Drug synergy studies in 3D spheroids cultures of tumour cell lines |
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Supervisors: | Das Viswanath M.Sc., Ph.D. |
Available: | 2 |
Intended for: | Bachelor training |