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Academic title: MSc.
Phone: 585 632 144
Groups: BACHELOR STUDENT, DOCTORAL STUDENT, IMTM, LEM, MASTER STUDENT, STAFF

Doctoral training

Cytotoxic drugs molecular target identification by methods of cell biology and proteomics

Molecular target identification of biologically active molecules is a key factor facilitating rational design and preclinical development of potential drugs. Methods of cellular biology, chemical proteomics and mass spectrometry are developed and used for its purposes.

Specialization: Pediatrics
Status: Ongoing from 2016.

Master training

Proteomic profile of CCRF-CEM cell line treated by 5-fluorouracil

Status: Graduated from 2014 to 2016.

Bachelor training

Determination of the efficacy of 5-fluorouracil on line CCRF-CEM T

Status: Graduated from 2014 to 2014.

About me

I am a research assistant and Ph.D. candidate at the Institute of Molecular and Translational Medicine in Olomouc, Czech Republic. Since 2016 I have been participating in the research program Chemical Biology and Experimental Therapeutics, mainly focusing on new methods for molecular target identification, such as microscopy and proteomics methods. I joined the multi-omics group in 2020 and currently working on the proteomics part of the EATRIS-Plus project.

Journals

A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution. Chemistry- A European Journal. 2018, 24(19), 4957-4966, ISSN: 0947-6539, PMID: 29411907,
OŽDIAN, T., D. HOLUB, Z. MACEČKOVÁ, L. VARANASI, G. RYLOVÁ, J. ŘEHULKA, J. VÁCLAVKOVÁ, H. SLAVÍK, P. MOUDRÝ, P. ZNOJEK, J. STANKOVÁ, J. DE SANCTIS, M. HAJDÚCH, P. DŽUBÁK
Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells. Journal of Proteomics. 2017, 162, 73-85, ISSN: 1874-3919, PMID: 28478306,
Identification of cellular targets of active substances using microscopic methods and fluorescent probes. Chemicke Listy. 2024, 118(3), 146-153, ISSN: 0009-2770,  PDF.