Dvořáková Bendová Kateřina

Multimodal imaging for in vivo testing of selected biomolecules

Invasive microbial infections are one of the main causes of morbidity and mortality in immunocompromised patients. Early and accurate diagnosis is the key factor of a successful treatment. Siderophores are low-molecular-mass molecules that are produced by almost all microorganisms and used for iron acquisition. Iron is an essential nutrient for many microorganisms and its need is increased during active infection. Replacing iron with suitable radionuclide, such as gallium-68, could enable the detection of microbial infections by means of molecular imaging.

Researcher and Ph.D. candidate at the Institute of Molecular and Translational Medicine in the field of radiopharmacy and molecular imaging. My research is focused on radiolabeled compounds for microPET/SPECT/MRI/CT imaging, in vitro analysis of radiolabeled compounds (radio-HPLC, radio-iTLC, gamma counter analysis) and in vivo/ex vivo biodistribution studies. The aim of my research is to develop a novel probe for imaging of pulmonary bacterial infections.

Orcid: https://orcid.org/0000-0001-6681-0100