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Academic title: Associate Professor
Phone: +420 585 632 197
Groups: IMTM, LEM, STAFF, SUPERVISOR

About me

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X 

Researcher ID: C-9611-2010 

Journals

GONZALES, G., J. HODOŇ, A. KAZAKOVA, C. D´ACUNTO, P. KANOVSKY, M. URBAN, M. STRNAD
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models. European Journal of Medicinal Chemistry. 2021, 213, 113168, ISSN: 0223-5234, PMID: 33508480,
URBAN, M., V. ŠLACHTOVÁ, L. BRULÍKOVÁ
Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 2021, 212, 113139, ISSN: 0223-5234, PMID: 33422979,
CHASÁK, J., V. ŠLACHTOVÁ, M. URBAN, L. BRULÍKOVÁ
Squaric acid analogues in medicinal chemistry. European Journal of Medicinal Chemistry. 2021, 209, 112872, ISSN: 0223-5234, PMID: 33035923,

Master mentorship

Šebrle Marek

Study on metathesis triterpenoids with exoskeletarnimi double bonds

Status: Graduated from 2011 to 2017.

Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Status: Graduated from 2020 to 2022.

Jurčeka Ondřej

Triterpenes modified at the position 30

Status: Graduated from 2020 to 2022.

Bachelor mentorship

Trhlíková Zdeňka

Preparation of heterocyclic triterpenes

Status: Graduated from 2013 to 2017.

Jurčeka Ondřej

Triterpenes modified at the position 30

Status: Graduated from 2018 to 2020.

Hodoň Jiří

Attempt to find the mechanizm of action in cytotoxic active triterpenes

Status: Graduated from 2012 to 2015.

Open positions

2 Molecular and Translational Medicine
Project: Modifications of biologically active molecules leading to improvement of their pharmacological properties
Supervisors: Urban Milan Ph.D., Ranc Václav Ph.D., Polishchuk Pavlo Ph.D., M.Sc.
Available: 3
Intended for: Doctoral training
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training