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Academic title: Associate Professor
Phone: +420 585 632 197
Groups: IMTM, LEM, STAFF, SUPERVISOR

About me

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X 

Researcher ID: C-9611-2010 

Journals

POKORNÝ, J., S. KRAJČOVIČOVÁ, M. HAJDÚCH, M. HOLOUBEK, S. GURSKÁ, P. DŽUBÁK, T. VOLNÁ, I. POPA, M. URBAN
Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM. Future Medicinal Chemistry. 2018, 10(5), 483-491, ISSN: 1756-8919, PMID: 29424548,
A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution. Chemistry- A European Journal. 2018, 24(19), 4957-4966, ISSN: 0947-6539, PMID: 29411907,
EIGNEROVA, B., M. TICHÝ, J. KRASULOVA, L. RÁROVÁ, R. CHRISTOVÁ, M. URBAN, B. BEDNARCZYK-CWYNAR, M. HAJDÚCH, J. ŠAREK
Q1_Synthesis and antiproliferative properties of new hydrophilic esters of triterpenic acids. European Journal of Medicinal Chemistry. 2017, 140, 403-420, ISSN: 0223-5234, PMID: 28987603,

Master mentorship

Tomeček Libor

Preparation of new complex platinum compounds using terpene ligands

Status: Ongoing from 2023.

Novák Jakub

Visualization of triterpenes in tumor cells

Status: Ongoing from 2023.

Bachelor mentorship

Vojtušová Lucie

Development of new triterpenoid derivatives with cytotoxic activity

Status: Ongoing from 2022.

Open positions

2 Molecular and Translational Medicine
Project: Modifications of biologically active molecules leading to improvement of their pharmacological properties
Supervisors: Urban Milan Ph.D., Ranc Václav Ph.D., Polishchuk Pavlo Ph.D., M.Sc.
Available: 3
Intended for: Doctoral training
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training