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Medicinal chemistry and bioactive natural products
Laboratory of Medicinal and Organic Chemistry
Our research group is currently focused on natural triterpenoids and their semi-synthetic analogues and on the studies of their biological activities. Based on the activities, we have two main domains of research.
- Compounds with anti-cancer activity
- Compounds with neuroprotective activity
Current projects
- Modifications of the position C-30 in lupane triterpenoids
- Triterpenoids with condensed heterocycle to the main skeleton
- Fluorescently labelled triterpenoids and their visualization in the living environment
- Bioorthogonal click-reaction of selectively cytotoxic triterpenes
- Development of compounds selectively cytotoxic in resistant cancer cells
- Compounds labelled with deuterium and their visualization using Raman confocal microscopy
- Natural products with neuroprotective properties and elucitation of their mechanism of action
Journals
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters.
European Journal of Medicinal Chemistry.
2021,
224,
113706,
ISSN: 0223-5234,
PMID: 34311159,
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models.
European Journal of Medicinal Chemistry.
2021,
213,
113168,
ISSN: 0223-5234,
PMID: 33508480,
Patents
C-28 BIOTINYLATED TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)
Patent: CZ 307229; Granted: 28.2.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan
Status: Terminated
C-28 BIOTINYLATED HETEROCYCLIC TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)
Patent: CZ 307 165; Granted: 3.1.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan
Status: Terminated
C-3 BIOTINYLATED TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)
Patent: CZ 307227; Granted: 28.2.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan
Status: Terminated
Books & book chapters
Biologically Active Triterpenoids Usable As Prodrugs,
1. vyd,
New York, USA,
Nova Science Publishers,
2015,
2,
25-50,
Dedication: CZ.1.05/2.1.00/01.0030,
ISBN: 978-1-63463-656-8,
Vývoj nových léčiv,
1. vyd,
Praha,
Galén,
2015,
11,
469-472,
ISBN: 978-80-7492-121-6,
The Potential of Triterpenoids in the Treatment of Melanoma,
1.vyd,
Rijeka,
InTech,
2011,
7,
125-158,
Dedication: 305/09/1216,
ISBN: 978-953-307-293-7,
Group leader
Group members
CHEMIE, ÚMTM, MEDCHEM, PERSONÁL
CHEMIE, ÚMTM, MEDCHEM, PERSONÁL
MEDCHEM, MAGISTERSKÝ STUDENT, BAKALÁŘSKÝ STUDENT
ÚMTM, LEM, PERSONÁL, VEDOUCÍ