Džubák Petr M.D., Ph.D.

Journals

VRZALOVA, A., P. PECINKOVA, S. GURSKÁ, P. DŽUBÁK, M. SZOTKOWSKI, M. HAJDÚCH, S. MANI, Z. DVORAK
Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity. International Journal of Molecular Sciences. 2022, 23(18), 10825, ISSN: 1422-0067, PMID: 36142735,  PDF.
ŘEHULKA, J., I. SUBTELNA, A. KRYSHCHYSHYN-DYLEVYCH, A. CHERNIIENKO, A. IVANOVA, M. MATVEIEVA, P. POLISHCHUK, S. GURSKÁ, M. HAJDÚCH, O. ZAGRIJTCHUK, P. DŽUBÁK, R. LESYK
Anticancer 5-arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones as tubulin inhibitors. Archiv der Pharmazie. 2022, 355(12), e2200419, ISSN: 0365-6233, PMID: 36109178,
BLANCO, Z., E. FERNANDEZ-MOREIRA, M. MIJARES, C. CELIS, G. MARTINEZ, J. DE SANCTIS, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, A. MIJOBA, Y. GARCIA, X. SERRANO, N. HERRERA, J. CORREA-ABRIL, Y. PARRA, J. ANGEL, H. RAMIREZ, J. CHARRIS
Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2 H)-one Derivatives. Molecules. 2022, 27(17), 5626, ISSN: 1420-3049, PMID: 36080388,  PDF.

Intellectual property

METHOD OF DIAGNOSIS AND/OR PROGNOSIS AND/OR PREDICTION OF THERAPEUTIC RESPONSE OF NEOPLASTIC DISEASES (Varanasi)
  1. Published Application EP 16153221.3 under EP 3199949 (2.8.2017)
  2. Published Application PCT/CZ2017/050003 under WO 2017/129154 (3.8.2017)

Status: Terminated

15BETA-SUBSTITUTED ESTRONE DERIVATIVES AS SELECTIVE INHIBITORS OF 17BETA-HYDROXYSTEOID-DEHYDROGENASES, METHOD OF PREPARATION AND USE THEREOF (Kotora)
  1. Patent: CZ 307437. Granted: 11.7.2018. Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Helmholtz Zentrum Munchen GmbH, Institute of Molecular Genetics, Palacký University, Olomouc, Inventors: Kotora Martin, Prchalová Eva, Adamski Jerzy, Moller Gabriele, Štěpánek Ondřej, Bartůněk Petr, Sedlák David, Džubák Petr, Hajdúch Marián
  2. Published Application PCT/CZ2017/050010 under WO 2017/148455 (8.9.2017)
  3. Published Application EP 17731057.0 under EP 3464314 (10.4.2019)
  4. Published Application AU 2017/276477 under AU 2017276477 (29.11.2018)
  5. Published Application CA 3.026.704 under CA 3026704 (14.12.2017)
  6. Published Application US 2017/16305829 under US 2019330258 (31.10.2019)

​Status: Terminated 

SUBSTITUTED THIENOPYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE (Hocek)
  1. Published Application PCT/CZ2016/050021 under WO 2018/001393 (4.1.2018)
  2. Patent: EP 3478701; Granted: 10.8.2022; Ownership: Institute of Organic Chemistry and Biochemistry CAS, Prague; Palacký University, Olomouc; Inventors: Hocek Michal, Tichý Michal, Hajdúch Marián, Džubák Petr
  3. Patent: US 10,414,788; Granted: 17.9.2019; Ownership: Institute of Organic Chemistry and Biochemistry CAS, Prague; Palacký University, Olomouc; Inventors: Hocek Michal, Tichý Michal, Hajdúch Marián, Džubák Petr
  4. Patent: JP 6650074; Granted: 21.1.2020;  Ownership: Institute of Organic Chemistry and Biochemistry CAS, Prague; Palacký University, Olomouc; Inventors: Hocek Michal, Tichý Michal, Hajdúch Marián, Džubák Petr
  5. Patent: CA 3.029.170; Granted: 16.2.2021; Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacky University, Olomouc; Inventors: Hocek Michal, Tichý Michal, Hajdúch Marián, Džubák Petr

Status: Terminated

Open positions

Project: Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Antitumor drugs targeting nucleic acid metabolism
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Identification of molecular targets and mechanisms of resistance in antitumor drugs using cell biology and proteomics methods
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Genetic and epigenetic biomarkers of cancer diseases
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 places in full-time study
Project: Identification of proteomic biomarkers in exhaled breath condensate in patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Ph.D. topic is focused on the identification of biomarkers of lung diseases by means of a non-invasive collection of exhaled breath condensate. The project will monitor the presence of proteins in exhaled air in various diseases such as asthma, cystic fibrosis, lung tumors, or some infectious diseases, as well as quantitative changes of these proteins compared to a healthy population. Changes in these potential biomarkers with respect to therapeutic response and disease progression will be evaluated and validated.
Project: Identification of molecular targets of anticancer therapy applying cell biology and proteomics tools
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Selected, highly active derivatives of triterpenes, chelators and nucleosides will be studied with a view to identify the mechanisms of their antitumor effects. Advanced methods of cell biology, proteomics and genomics such as affinity purification of protein targets, CETSA and others will be used for their study. The identified targets will be validated in relation to their clinical relevance in anticancer therapy.
Project: Drug resistance mechanisms in cancer
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Mechanisms of tumor cell resistance to newly developed and existing nucleoside analog cytostatics will be studied. These drugs are used in most anti-cancer therapy protocols and the emergence of drug resistance is a major problem in the treatment of cancer patients. Resistant cell lines prepared in the past will be studied to identify the key mechanisms of resistance, which will be carried out by their detailed characterization using cell biology, but also proteomics and molecular genetics. The significance of the identified changes will be further verified on clinical material and will be applied in the development of new anticancer drugs from this class.
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Genetic and epigenetic biomarkers in health and disease
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
Available: 5
Intended for: Doctoral training
Project: Identification of molecular targets and resistance mechanisms of anticancer drugs by cell biology and proteomics methods
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in proximal fluids and tissues
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Innovative approaches to protein interaction modifiers
Supervisors: Džubák Petr M.D., Ph.D., Václavková Jana M.Sc.
Available: 1
Intended for: Doctoral training
Project: Utilization of the space of unprecedented covalent inhibitors
Supervisors: Džubák Petr M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Project: Anticancer drugs targeting nucleic acid metabolism
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training