Mistrík Martin Ph.D.
About me
Specializing in cellular stresses and their link to cancer development and treatment. Another specialization includes advanced microscopic techniques (the head of the bioimaging core facility: https://imtm.cz/core-facilities/bioimaging-core-facility ). Actively participated in the research of more than 10 national and international projects. Published more than >40 original investigations and three patents, >3000 citations, H-index 24
Journals
Identification of novel dithiocarbamate-copper complexes targeting p97/NPL4 pathway in cancer cells.
European Journal of Medicinal Chemistry.
2023,
261,
115790,
ISSN: 0223-5234 ,
PMID: 37690264,
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET.
Cell Death and Differentiation.
2023,
ISSN: 1350-9047,
PMID: 37142656,
Cannabis-derived products antagonize platinum drugs by altered cellular transport.
Biomedicine & Pharmacotherapy.
2023,
163,
114801,
ISSN: 0753-3322,
PMID: 37137184,
Books & book chapters
Quantitative immunofluorescence microscopy ,
1.vyd.,
Olomouc,
Palacky University,
2021,
14,
89-100,
Dedication: LO1304,
ISBN: 978-80-244-6049-9,
Laboratory Techniques in Cellular and Molecular Medicine,
1.vyd.,
Olomouc,
Palacky University,
2021,
436 s,
Dedication: LO1304,
ISBN: 978-80-244-6049-9,
Intellectual property
MCOPPB FOR USE AS MEDICAMENT (Mistrík)
- Published Application EP 18166780.9 under EP 3552605 (16.10.2019)
- Published Application PCT/CZ2019/059320 under WO 2019/197564 (17.10.2019)
Status: Patent pending, Available
BIOAVAILABLE DITHIOCARBAMATE-METAL COMPLEX NANOPARTICLES, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM I" (Škrott)
- Patent: EP 3459526. Granted: 24.2.2021. Ownership: Palacky University, Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Published Application PCT/EP2018/076098 under WO 2019/063601 (4.4.2019)
- Patent: AU 2018340510. Granted: 5.8.2021. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Patent: CA 3,076,855. Granted: 26.4.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Patent: KR 10-2456683. Granted: 14.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Patent: JP 2020-537873. Granted: 29.9.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Patent: MX 396,552. Granted: 17.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
Status: Available
METHOD OF OBTAINING FOLLICULAR CELLS AND A DEVICE FOR CARRYING OUT THIS METHOD (Mistrík)
- Patent: CZ 304255; Granted: 18.12.2013; Ownership: Palacky University Olomouc; Inventors: Mistrík Martin, Bártek Jiří
- Published Application PCT/CZ2013/000152 under WO 2014/086324 (12.6.2014)
- Patent: US 9,943,331; Granted: 17.4.2018; Ownership: Palacky University Olomouc; Inventors: Mistrík Martin, Bártek Jiří
- Patent: EP 2928382; Granted: 26.12.2018; Ownership: Palacky University Olomouc; Inventors: Mistrík Martin, Bártek Jiří
- EU Registered Trademark: EUTM 018714735; Registered: 8.11.2022; Ownership: Palacky University Olomouc
Status: Available
Doctoral mentorship
Škrott Zdeněk Ph.D.
The role of the ubiquitin-proteasome system in tumorigenesis and cancer treatment
Status:
Graduated from 2014 to 2019.
Buchtová Tereza M.Sc.
Proteotoxic stress
Status:
Graduated from 2018 to 2023.
Veselá Eva M.Sc.
Application of quantitative microscopy analysis of DNA damage for study of cell response to γ-irradiation and radiomimetic compounds in different genetic backrounds.
Status:
Graduated from 2011 to 2017.
Master mentorship
Veselá Eva M.Sc.
Quantitative analysis of DNA damage markers and optimization of the methods for routine screening of potentially genotoxic compounds and factors
Status:
Graduated from 2009 to 2011.
Votroubek Ondřej
Effect of CuET and DNA damage inductors on DNA replication in cancer cells
Status:
Graduated from 2021 to 2023.
Bachelor mentorship
Veselá Eva M.Sc.
Identification and quantification of DNA damage in human cells
Status:
Graduated from 2008 to 2009.
Open positions
| Project: | DNA damage signaling in the cellular response to stress |
|---|---|
| Supervisors: | Mistrík Martin Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Signaling DNA damage in cellular response to stress |
|---|---|
| Supervisors: | Mistrík Martin Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | Our DNA is constantly under threat from DNA damaging agents. If unrepaired DNA damage can lead to errors during genome duplication, including the mutations that can lead to cancer, contribute to aging and other human diseases. Cells have evolved elaborate repair mechanisms to fix this damage and ensure that the genetic information is faithfully reproduced, and we would like to understand these repair mechanisms at the molecular level. We ultimately aim for a complete molecular and cellular understanding of critical DNA repair pathways that act on DNA damage. The Ph.D. student will practice several molecular and cellular techniques, including cell culture, RNA interference, immunofluorescence microscopy, live-cell imaging and immunoprecipitation of proteins. He/she will also learn novel and powerful techniques, such as super-resolution microscopy and purification of proteins on newly synthesized DNA. |
| Project: | Study of DNA double-strand break repair in tumor model |
|---|---|
| Supervisors: | Mistrík Martin Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | The so-called double-strand breaks (DSB) are the most lethal DNA lesions, which can be potent sources of mutations and thus become the beginning of irreversible genetic changes leading to degenerative illnesses, including cancer. At the same induction of DSBs introduced in the proper setup can become an unsolvable problem for the cells, particularly in specific genetic backgrounds typical for cancer, which fact is the rationale for a plethora of cancer treatment strategies. Thus the way cells deal with DSBs is under the great interest of current medicinal and biological research. The Ph.D. student will practice several methods of induction of DSBs via various sources such as gamma rays, alpha particles, UV light and various chemical inducers. Next will be studied the molecular mechanisms the cell deal with this type of DNA damage. Emphasis will be put on differences between normal and cancer cells and their potential exploration for cancer therapy. Student will also learn mutiple laboratory techniques including cell culture, RNA/DNA transfections, advanced microscopic techniques, live-cell imaging, and various biochemical analysis of proteins. |
| Project: | Cellular stress in health and disease |
|---|---|
| Supervisors: | Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |
| Project: | DNA damage signaling in the cellular response to stress |
|---|---|
| Supervisors: | Mistrík Martin Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |