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Das Viswanath M.Sc., Ph.D.

Journals

ANNADURAI, N., L. MALINA, M. SALMONA, L. DIOMEDE, A. BASTONE, A. CAGNOTTO, M. ROMEO, M. SREJBER, K. BERKA, M. OTYEPKA, M. HAJDÚCH, V. DAS
Antitumour drugs targeting tau R3 VQIVYK and Cys322 prevent seeding of endogenous tau aggregates by exogenous seeds. FEBS Journal. 2021, 289(7), 1929-1949, ISSN: 1742-464X, PMID: 34743390,
Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies. Experimental Neurology. 2021, 343, 113756, ISSN: 0014-4886, PMID: 33989658,
KUGLER, M., J. NEKVINDA, J. HOLUB, S. EL ANWAR, V. DAS, V. SICHA, K. POSPISILOVA, M. FABRY, V. KRAL, J. BRYNDA, V. KASICKA, M. HAJDÚCH, P. ŘEZÁČOVÁ, B. GRUNER
Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds. Chembiochem : a European Journal of Chemical Biology. 2021, 22(18), 2741-2761, ISSN: 1439-4227, PMID: 33939874,

Master mentorship

Smrčková Helena

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Status: Ongoing from 2023.

Open positions

Project: The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: A combination of 2D and 3D cell cultures for a smart and effective identification and characterization of anti-hypoxic candidates
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: Hypoxia is a prominent feature of different solid tumor types. A central component of hypoxic adaptation is the stabilization of hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator of hypoxia that orchestrates the transcriptional regulation of genes involved in a plethora of cellular processes. Considering the multiple roles of HIF-1 in cancer, interest in novel small-molecule inhibitors of the HIF-1 pathway has steadily increased over the past 10 years. However, despite extensive research, no specific inhibitor of HIF-1 has been brought to the market, making the field still ripe for further exploration. The goal of the present work is to utilize the potential of a combination of 2D and 3D cellular models for identification and characterization of inhibitors of HIF-1 and/or HIF-1 pathway by screening in 2D cultures, and lightsheet microscopy and mass spectrometry studies in spheroid cultures.
Project: An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies
Project: The role of tumor hypoxia in the acquisition of resistance to microtubule-targeting drugs
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: Hypoxia is one of the major factors causing resistance to microtubule-stabilizing drugs (MSDs) and other non-microtubule drugs used in chemotherapy. Hypoxia results in changes in tubulin conformation, expression of tubulin isotypes and metabolic pathways that make cancer cells less susceptible to paclitaxel, a taxane used extensively in the treatment of solid tumors. Recent cellular studies have shown that non-taxane MSDs with a similar mode of microtubule stabilization to paclitaxel is more effective in hypoxic cancer cells than paclitaxel. Due to a different microtubule-binding site, we hypothesize that non-taxane MSDs may have a better cytotoxic effect in cancer cells under hypoxia. The goal of this project is to study the anti-cancer effect of non-taxane MSDs in hypoxic ovarian and cervical cancer cell models.
Project: Systems approaches to understanding aging and neurodegeneration
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Doctoral training
Project: The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Role of axonal transport and pathology in neurodegeneration
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Development of organoid assays for anti-tumour drug screening
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Bachelor training
Project: Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Bachelor training
Project: Drug synergy studies in 3D spheroids cultures of tumour cell lines
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Bachelor training