Hekele Richard

Synthesis of trisubstituted derivatives of 4H-benzo triazole diazepin one on solid phase using an alpha-amino acid

This work is based on the solid-phase synthesis of trisubstituted 4H-benzotriazolodiazepinone derivatives utilizing alpha-amino acids. Used procedure comes from recently published findings of Fülöpová and Soural, and it is aimed at the synthesis of small library followed by biological screening (especially CNS activity).