Srovnal Josef M.D., Ph.D.

Journals

BERTA, E., J. SROVNAL, P. DYTRYCH, J. BRUTHANS, J. ULRICHOVÁ, P. PRASIL, L. VECERA, T. GABRHELIK, B. TOLMACI, J. DUSA, J. MACA, M. MAZACOVA, F. HAJDUK, M. KUTEJ, P. IHNAT, P. MICHALEK, M. HAJDÚCH
Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial. BMC Anesthesiology. 2023, 23(1), 64, ISSN: 1471-2253, PMID: 36855089,
VIDLAŘOVÁ, M., A. ŘEHULKOVÁ, P. STEJSKAL, A. PROKOPOVÁ, H. SLAVÍK, M. HAJDÚCH, J. SROVNAL
Recent Advances in Methods for Circulating Tumor Cell Detection. International Journal of Molecular Sciences. 2023, 24(4), 3902, ISSN: 1422-0067, PMID: 36835311,
KOLEČKOVÁ, M., M. BEZDEKOVA, J. BOUCHAL, M. JANÍKOVÁ, J. BOHOSOVA, O. SLABÝ, M. SVOBODA, J. SROVNAL, K. VOMACKOVA, I. ÜBERALL, Z. KOLÁŘ
Challenges of in situ hybridization in miRNA analysis of triple-negative breast cancer morphological diversity. Neoplasma. 2023, ISSN: 0028-2685, PMID: 36812229,

Books & book chapters

DRÁBEK, J., V. DAS, P. DŽUBÁK, J. SROVNAL, J. BOUCHAL, M. HAJDÚCH, K. KOBERNA, A. LIGASOVÁ, M. MISTRÍK, J. DE SANCTIS
Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,
SROVNAL, J.
Elektrochemické metody, (bio)senzory a čipové platformy, 1.vyd., korigovaný dotisk, Olomouc, Univerzita Palackého v Olonouci, 2021, 2.3, 43-52, ISBN: 978-80-244-3951-8,
SROVNAL, J.
Onkogenetika, 1.vyd., Olomouc, Univerzita Palackého v Olomouci, 2018, 109-116, ISBN: 978-80-244-5368-2,

Doctoral mentorship

Stejskal Pavel MSc

Circulating tumor cells detection

Status: Ongoing from 2020.

Master mentorship

Slavík Hanuš M.Sc.

Effect of analgesia on circulating tumor cells levels in colorectal cancer patients

Status: Graduated from 2012 to 2014.
Juřicová Markéta

Mechanism of phenretinide action and effect on miRNA expression in cystic fibrosis models

Status: Graduated from 2019 to 2021.
Rožková Markéta

Molecular characterization of circulating tumor cells in cancer patients

Status: Graduated from 2022 to 2023.

Bachelor mentorship

Svatošová Barbora

Detection of somatic mutations and selected cytogenetic changes in gliomas

Status: Graduated from 2021 to 2023.
Mikuláštíková Michaela

Revision of the variants of unclear significance (VUS) in patients tested for hereditary cancer syndromes in the context of the results of the A-C-G-T project

Status: Graduated from 2021 to 2023.
Resutíková Lucie

Telomerase in solid tumors

Status: Graduated from 2008 to 2008.

Open positions

Project: Diagnostics and therapy of rare diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: New prognostic and predictive factors in solid tumors
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 places in full-time or combined form of study
Project: New prognostic and predictive factors in solid tumors
Supervisors: Srovnal Josef M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Cancer is the second leading cause of death in the western countries. Early diagnosis and targeted therapy improve the therapeutic outcome. With the emergence of new biotechnologies, diagnosis can be made early and precisely, and the knowledge of tumor molecular genetics can identify the most appropriate therapy for a particular patient. The sensitivity of modern molecular methods makes it possible to characterize the tumor properties from sites remote from the primary tumor using patient's blood. The subject of the offered study program is the identification of new prognostic and predictive biomarkers of cancer using liquid biopsies. This is particularly the analysis of circulating tumor cells (CTCs), circulating free tumor DNA (ctDNA) and circulating miRNAs. The aim of the project is to further implement a liquid biopsy concept into the diagnosis and therapy monitoring of solid tumors, especially colorectal, breast, lung and CNS tumors. These include therapy response and resistance monitoring, identifying new therapeutic targets and estimating disease prognosis. The project will provide training in widely-used, transferable techniques, including circulation tumor cells capture system, digital droplet PCR, reverse-transcription qPCR, RNA-seq, single cell analyses, xenografts models and other multi-omics methods. We are looking for candidates with a background in Molecular Biology, Medicine, Cell Biology or a related area, who are enthusiastic about investigating novel approaches in cancer diagnostic that have significant potential for public health.
Project: Diagnosis and treatment of rare diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: New prognostic and predictive factors in solid tumors
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D.
Available: 3
Intended for: Doctoral training
Project: Liquid biopsies in experimental and clinical oncology
Supervisors: Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D.
Available: 2
Intended for: Doctoral training