Urban Milan Ph.D.

Journals

BACHOŘÍK, J., M. URBAN
Biocatalysis in the Chemistry of Lupane Triterpenoids. Molecules. 2021, 26(8), 2271, ISSN: 1420-3049, PMID: 33919839,  PDF.
GONZALES, G., J. HODOŇ, A. KAZAKOVA, C. D´ACUNTO, P. KANOVSKY, M. URBAN, M. STRNAD
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models. European Journal of Medicinal Chemistry. 2021, 213, 113168, ISSN: 0223-5234, PMID: 33508480,
URBAN, M., V. ŠLACHTOVÁ, L. BRULÍKOVÁ
Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 2021, 212, 113139, ISSN: 0223-5234, PMID: 33422979,

Intellectual property

C-28 BIOTINYLATED TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307229; Granted: 28.2.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan

​Status: Terminated 

TRITERPENES WITH INHIBITORY ACTIVITY ON THE HEDGEHOG SIGNALING PATHWAY FOR USE IN THE TREATMENT OF CANCER DISEASES (Urban)
  1. Priority Application: PV 2022-277. Filed: 21.6.2022. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián. Ownership: Palacký University Olomouc. 

Status: Patent pending; Available

Doctoral mentorship

Borková Lucie Ph.D.

Modification of triterpenes with the use of transition metal catalyzed reactions and nucleophilic substitution

Status: Graduated from 2014 to 2018.
Pokorný Jan

Modifications of double bonds in triterpenes with antitumor activity

Status: Graduated from 2015 to 2022.
Hodoň Jiří

Cytotoxic active triterpenes and their mechanism of action

Status: Ongoing from 2017.

Master mentorship

Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Status: Graduated from 2018 to 2020.
Šidová Veronika

Synthesis of new cytotoxic triterpenoid derivatives using click chemistry

Status: Graduated from 2013 to 2015.
Zoufalý Pavel

Exploraton of click reaction approach in triterpenoids containing propargyl substituent

Status: Graduated from 2014 to 2016.

Bachelor mentorship

Horka Vladimír

Conjugates of betulin prepared by cycloaddition reactions

Status: Graduated from 2016 to 2018.
Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Status: Graduated from 2016 to 2018.
Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Status: Graduated from 2018 to 2020.

Open positions

Project: Modifications of biologically active molecules leading to improvement of their pharmacological properties
Supervisors: Urban Milan Ph.D., Ranc Václav Ph.D., Polishchuk Pavlo Ph.D., M.Sc.
Available: 3
Intended for: Doctoral training
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training