Urban Milan Ph.D.

Journals

POKORNÝ, J., D. OLEJNÍKOVÁ, I. FRYDRYCH, B. LIŠKOVÁ, S. GURSKÁ, S. BENICKÁ, J. ŠAREK, J. KOTULOVÁ, M. HAJDÚCH, P. DŽUBÁK, M. URBAN
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters. European Journal of Medicinal Chemistry. 2021, 224, 113706, ISSN: 0223-5234, PMID: 34311159,
BACHOŘÍK, J., M. URBAN
Biocatalysis in the Chemistry of Lupane Triterpenoids. Molecules. 2021, 26(8), 2271, ISSN: 1420-3049, PMID: 33919839,  PDF.
GONZALES, G., J. HODOŇ, A. KAZAKOVA, C. D´ACUNTO, P. KANOVSKY, M. URBAN, M. STRNAD
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models. European Journal of Medicinal Chemistry. 2021, 213, 113168, ISSN: 0223-5234, PMID: 33508480,

Intellectual property

C-28 BIOTINYLATED TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307229; Granted: 28.2.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan

​Status: Terminated 

TRITERPENES WITH INHIBITORY ACTIVITY ON THE HEDGEHOG SIGNALING PATHWAY FOR USE IN THE TREATMENT OF CANCER DISEASES (Urban)
  1. Priority Application: PV 2022-277. Filed: 21.6.2022. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián. Ownership: Palacký University Olomouc. 

Status: Patent pending; Available

Doctoral mentorship

Borková Lucie Ph.D.

Modification of triterpenes with the use of transition metal catalyzed reactions and nucleophilic substitution

Status: Graduated from 2014 to 2018.
Pokorný Jan

Modifications of double bonds in triterpenes with antitumor activity

Status: Graduated from 2015 to 2022.
Hodoň Jiří

Cytotoxic active triterpenes and their mechanism of action

Status: Ongoing from 2017.

Master mentorship

Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Status: Graduated from 2018 to 2020.
Šidová Veronika

Synthesis of new cytotoxic triterpenoid derivatives using click chemistry

Status: Graduated from 2013 to 2015.
Zoufalý Pavel

Exploraton of click reaction approach in triterpenoids containing propargyl substituent

Status: Graduated from 2014 to 2016.

Bachelor mentorship

Horka Vladimír

Conjugates of betulin prepared by cycloaddition reactions

Status: Graduated from 2016 to 2018.
Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Status: Graduated from 2016 to 2018.
Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Status: Graduated from 2018 to 2020.

Open positions

Project: Modifications of biologically active molecules leading to improvement of their pharmacological properties
Supervisors: Urban Milan Ph.D., Ranc Václav Ph.D., Polishchuk Pavlo Ph.D., M.Sc.
Available: 3
Intended for: Doctoral training
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training