Mistrík Martin Ph.D.
About me
Specializing in cellular stresses and their link to cancer development and treatment. Another specialization includes advanced microscopic techniques (the head of the bioimaging core facility: https://imtm.cz/core-facilities/bioimaging-core-facility ). Actively participated in the research of more than 10 national and international projects. Published more than >40 original investigations and three patents, >3000 citations, H-index 24
Journals
Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET.
Molecular Oncology.
2021,
16(7),
1541-1554,
ISSN: 1574-7891,
PMID: 34632694,
Microthermal-induced subcellular-targeted protein damage in cells on plasmonic nanosilver-modified surfaces evokes a two-phase HSP-p97/VCP response.
Nature Communications.
2021,
12(1),
713,
ISSN: 2041-1723,
PMID: 33514738,
Intellectual property
MOLECULAR COMPLEX ASSEMBLY PARTICLES COMRISING BIS-R1, R2-DITHIOCARBAMATE-METAL COMPLEX AND A LIGAND, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM II" (Mistrík)
- Published Application EP 18199181.1 under EP 3636285 (15.4.2020)
- Published Application PCT/EP2019/077222 under WO 2020/074514 (16.4.2020)
- Patent: AU 2019358428. Granted: 4.8.2022. Ownership: Palacky University Olomouc. Inventors: Mistrík Martin, Bártek Jiří, Škrott Zdeněk, Džubák Petr, Hajdúch Marián
- Patent: JP 7220932. Granted: 3.2.2023. Ownership: Palacky University Olomouc. Inventors: Mistrík Martin, Bártek Jiří, Škrott Zdeněk, Džubák Petr, Hajdúch Marián
Status: Patents pending, Available
METHOD OF PRODUCTION OF SYNCHRONIZED ADHERENTLY GROWING CELL LINES AND DEVICE FOR CARRYING OUT SAID METHOD (Mistrík)
- Patent: CZ 302682; Granted: 20.7.2011; Ownership: Palacky University Olomouc; Inventors: Mistrík Martin, Bártek Jiří
- Published Application PCT/CZ2010/000043 under WO 2010/118709 (21.10.2010)
- Patent: EP 2419503; Granted: 19.12.2012; Ownership: Palacky University Olomouc; Inventors: Mistrík Martin, Bártek Jiří
Status: Terminated
Open positions
| Project: | DNA damage signaling in the cellular response to stress |
|---|---|
| Supervisors: | Mistrík Martin Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Signaling DNA damage in cellular response to stress |
|---|---|
| Supervisors: | Mistrík Martin Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | Our DNA is constantly under threat from DNA damaging agents. If unrepaired DNA damage can lead to errors during genome duplication, including the mutations that can lead to cancer, contribute to aging and other human diseases. Cells have evolved elaborate repair mechanisms to fix this damage and ensure that the genetic information is faithfully reproduced, and we would like to understand these repair mechanisms at the molecular level. We ultimately aim for a complete molecular and cellular understanding of critical DNA repair pathways that act on DNA damage. The Ph.D. student will practice several molecular and cellular techniques, including cell culture, RNA interference, immunofluorescence microscopy, live-cell imaging and immunoprecipitation of proteins. He/she will also learn novel and powerful techniques, such as super-resolution microscopy and purification of proteins on newly synthesized DNA. |
| Project: | Study of DNA double-strand break repair in tumor model |
|---|---|
| Supervisors: | Mistrík Martin Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | The so-called double-strand breaks (DSB) are the most lethal DNA lesions, which can be potent sources of mutations and thus become the beginning of irreversible genetic changes leading to degenerative illnesses, including cancer. At the same induction of DSBs introduced in the proper setup can become an unsolvable problem for the cells, particularly in specific genetic backgrounds typical for cancer, which fact is the rationale for a plethora of cancer treatment strategies. Thus the way cells deal with DSBs is under the great interest of current medicinal and biological research. The Ph.D. student will practice several methods of induction of DSBs via various sources such as gamma rays, alpha particles, UV light and various chemical inducers. Next will be studied the molecular mechanisms the cell deal with this type of DNA damage. Emphasis will be put on differences between normal and cancer cells and their potential exploration for cancer therapy. Student will also learn mutiple laboratory techniques including cell culture, RNA/DNA transfections, advanced microscopic techniques, live-cell imaging, and various biochemical analysis of proteins. |
| Project: | Cellular stress in health and disease |
|---|---|
| Supervisors: | Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |
| Project: | DNA damage signaling in the cellular response to stress |
|---|---|
| Supervisors: | Mistrík Martin Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |