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Džubák Petr M.D., Ph.D.

Journals

Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,
YANG, C., L. POSTOVA SLAVETINSKA, M. FLEUTI, B. KLEPETAROVA, M. TICHÝ, S. GURSKÁ, P. PAVLIŠ, P. DŽUBÁK, M. HAJDÚCH, M. HOCEK
Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling. Journal of the American Chemical Society. 2022, 144(42), 19437-19446, ISSN: 0002-7863, PMID: 36245092,
HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412,  PDF.

Intellectual property

BENZOTHIAZOLE-SUBSTITUTED CYCLOBUT-3-ENE-1, 2-DIONE-3-HYDRAZONES AND THEIR USE IN THE TREATMENT OF VARIOUS TYPES OF LEUKEMIA AND TUMOUR DISEASES (Kaplánek)
  1. Patent: CZ 305538; Granted: 14.10.2015; Ownership: Institute of Chemical Technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS; Inventors: Kaplánek Robert, Bříza Tomáš, Havlík Martin, Rak Jakub, Kejík Zdeněk, Krejčí Petr, Džubák PetrHajdúch Marián, Štěpánková Jana, Konečný Petr, Králová Jarmila, Král Vladimír 

Status: Terminated

CHOLYL HYDRAZONES AND THEIR USE IN THE TREATMENT OF TUMOR AND LEUKEMIA DISEASES (Rak)
  1. Patent: CZ 305607; Granted: 25.11.2015; Ownership: Institute of Chemical Technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS; Inventors: Rak Jakub, Kaplánek Robert, Štulcová Tereza, Drašar Pavel, Havlík Martin, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Terminated

METHOD OF IDENTIFICATION OF ENTITIES FROM MASS SPECTRA (Hruška)
  1. Published Application EP 18184710.4 under EP 3598135 (22.1.2020)
  2. Published Application PCT/EP2019/069552 under WO 2020/016428 (23.1.2020)
  3. Published Application EP 19746050.4 under EP3824292 (26.5.2021)
  4. Patent: JP 7218019. Granted: 27.1.2023. Ownership: Palacký University Olomouc. Inventors: Hruška Miroslav, Hajdúch Marián

Status: Patents pending, Available

Doctoral mentorship

Oždian Tomáš Ph.D.

Cancer proteomics in clinical and experimental oncology

Status: Graduated from 2009 to 2016.
Balatková Pavlína

Experimental development of drugs and nanoparticles targeting prototoxic stress

Status: Ongoing from 2023.
Kroupová Denisa

Multi Omics analyzes of proximal fluids for the identification of novel biomarkers and molecular targets

Status: Ongoing from 2023.

Open positions

Project: Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Antitumor drugs targeting nucleic acid metabolism
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Identification of molecular targets and mechanisms of resistance in antitumor drugs using cell biology and proteomics methods
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Genetic and epigenetic biomarkers of cancer diseases
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 places in full-time study
Project: Identification of proteomic biomarkers in exhaled breath condensate in patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Ph.D. topic is focused on the identification of biomarkers of lung diseases by means of a non-invasive collection of exhaled breath condensate. The project will monitor the presence of proteins in exhaled air in various diseases such as asthma, cystic fibrosis, lung tumors, or some infectious diseases, as well as quantitative changes of these proteins compared to a healthy population. Changes in these potential biomarkers with respect to therapeutic response and disease progression will be evaluated and validated.
Project: Identification of molecular targets of anticancer therapy applying cell biology and proteomics tools
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Selected, highly active derivatives of triterpenes, chelators and nucleosides will be studied with a view to identify the mechanisms of their antitumor effects. Advanced methods of cell biology, proteomics and genomics such as affinity purification of protein targets, CETSA and others will be used for their study. The identified targets will be validated in relation to their clinical relevance in anticancer therapy.
Project: Drug resistance mechanisms in cancer
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Mechanisms of tumor cell resistance to newly developed and existing nucleoside analog cytostatics will be studied. These drugs are used in most anti-cancer therapy protocols and the emergence of drug resistance is a major problem in the treatment of cancer patients. Resistant cell lines prepared in the past will be studied to identify the key mechanisms of resistance, which will be carried out by their detailed characterization using cell biology, but also proteomics and molecular genetics. The significance of the identified changes will be further verified on clinical material and will be applied in the development of new anticancer drugs from this class.
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Genetic and epigenetic biomarkers in health and disease
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
Available: 5
Intended for: Doctoral training
Project: Identification of molecular targets and resistance mechanisms of anticancer drugs by cell biology and proteomics methods
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in proximal fluids and tissues
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Innovative approaches to protein interaction modifiers
Supervisors: Džubák Petr M.D., Ph.D., Václavková Jana M.Sc.
Available: 1
Intended for: Doctoral training
Project: Utilization of the space of unprecedented covalent inhibitors
Supervisors: Džubák Petr M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Project: Anticancer drugs targeting nucleic acid metabolism
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training